| Name | adenylyl cyclase |
|---|---|
| Synonyms | ADCY 7; ATP pyrophosphate lyase; Adenylyl cyclase; ADCY7; ADCY7 protein; ATP pyrophosphate lyase 7; Adenylate cyclase 7; Adenylate cyclase type 7… |
| Name | chlorpyrifos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10837889 | Auman JT, Seidler FJ, Slotkin TA: Neonatal chlorpyrifos exposure targets multiple proteins governing the hepatic adenylyl cyclase signaling cascade: implications for neurotoxicity. Brain Res Dev Brain Res. 2000 May 11;121(1):19-27. |
112(1,2,2,2) | Details |
| 11164809 | Garcia SJ, Seidler FJ, Crumpton TL, Slotkin TA: Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive in C6 glioma cells. Brain Res. 2001 Feb 9;891(1-2):54-68. |
82(1,1,1,2) | Details |
| 20298678 | Adigun AA, Ryde IT, Seidler FJ, Slotkin TA: Organophosphate Exposure During a Critical Developmental Stage Reprograms Adenylyl Cyclase Signaling in PC12 Cells. Brain Res. 2010 Mar 15. We exposed PC12 cells to chlorpyrifos, diazinon or parathion in the undifferentiated state and during neurodifferentiation; we then assessed the function of the adenylyl cyclase (AC) signaling cascade, measuring basal AC activity as well as responses to stimulants acting at G-proteins or on the AC molecule itself. |
82(1,1,1,2) | Details |
| 17805420 | Slotkin TA, MacKillop EA, Ryde IT, Seidler FJ: Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells. Environ Health Perspect. 2007 Sep;115(9):1306-13. OBJECTIVES: We evaluated mechanisms contributing to the adverse effects of chlorpyrifos (CPF) on DNA synthesis, cell number and size, and cell signaling mediated by adenylyl cyclase (AC) in PC12 cells, a neuronotypic cell line that recapitulates the essential features of developing mammalian neurons. |
81(1,1,1,1) | Details |
| 9221834 | Song X, Seidler FJ, Saleh JL, Zhang J, Padilla S, Slotkin TA: Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade. Toxicol Appl Pharmacol. 1997 Jul;145(1):158-74. Developmental neurotoxicity caused by chlorpyrifos exposure is generally thought to target cholinesterase but chlorpyrifos may also act on cellular intermediates, such as adenylyl cyclase, that serve global functions in the coordination of cell development. |
74(0,2,4,4) | Details |
| 14644659 | Meyer A, Seidler FJ, Cousins MM, Slotkin TA: Developmental neurotoxicity elicited by gestational exposure to chlorpyrifos: when is adenylyl cyclase a target?. Environ Health Perspect. 2003 Dec;111(16):1871-6. |
32(0,1,1,2) | Details |
| 14998743 | Meyer A, Seidler FJ, Aldridge JE, Tate CA, Cousins MM, Slotkin TA: Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure. Environ Health Perspect. 2004 Mar;112(3):295-301. |
7(0,0,1,2) | Details |
| 20026089 | Adigun AA, Seidler FJ, Slotkin TA: Disparate developmental neurotoxicants converge on the cyclic AMP signaling cascade, revealed by transcriptional profiles in vitro and in vivo. Brain Res. 2010 Feb 26;1316:1-16. Epub 2009 Dec 21. We compared organophosphates (chlorpyrifos, diazinon), an organochlorine (dieldrin) and a metal (Ni (2+)) for their effects on neuronotypic PC12 cells, assessing gene transcription involved in the cyclic AMP pathway. Each agent was introduced during neurodifferentiation at a concentration of 30 microM for 24 or 72 h and we assessed 69 genes encoding adenylyl cyclase isoforms and regulators, G-protein alpha-and beta,gamma-subunits, protein kinase A subtypes and the phosphodiesterase family. |
2(0,0,0,2) | Details |
| 11572272 | Thrasher JD, Kilburn KH: Embryo toxicity and teratogenicity of . Arch Environ Health. 2001 Jul-Aug;56(4):300-11. For example, chlorpyrifos has not produced teratogenic effects in rats when mothers are exposed on days 6-15 (Katakura Y, et al. These effects included neuroapoptosis, decreased deoxyribonucleic acid and ribonucleic acid synthesis, abnormalities in adenylyl cyclase cascade, and neurobehavioral effects (Johnson DE, et al. |
1(0,0,0,1) | Details |
| 14594624 | Aldridge JE, Seidler FJ, Meyer A, Thillai I, Slotkin TA: Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods. Environ Health Perspect. 2003 Nov;111(14):1736-43. We also identified major alterations in 5HT-mediated responses, assessed for the adenylyl cyclase signaling cascade. |
1(0,0,0,1) | Details |
| 15710174 | Aldridge JE, Meyer A, Seidler FJ, Slotkin TA: Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions. Toxicol Appl Pharmacol. 2005 Mar 1;203(2):132-44. Both altered 5HT receptor-mediated cell signaling, suppressing stimulatory effects on adenylyl cyclase and enhancing inhibitory effects. |
1(0,0,0,1) | Details |
| 11876500 | Zhang H, Liu J, Pope CN: Age-related effects of chlorpyrifos on muscarinic receptor-mediated signaling in rat cortex. Arch Toxicol. 2002 Jan;75(11-12):676-84. These results provide further evidence that the cortical cAMP signaling pathway may be particularly sensitive to CPF exposure in neonatal, juvenile, and adult rats, possibly due to a direct interaction between CPF (or its oxon) and mAChRs or other components of the adenylyl cyclase cascade. |
1(0,0,0,1) | Details |
| 14754571 | Meyer A, Seidler FJ, Slotkin TA: Developmental effects of chlorpyrifos extend beyond neurotoxicity: critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling. Environ Health Perspect. 2004 Feb;112(2):170-8. In the present study, we evaluated the immediate and long-term effects of CPF exposure of rats during different developmental windows [gestational days (GD) 9-12 or 17-20, postnatal days (PN) 1-4 or 11-14] on the adenylyl cyclase (AC) signaling cascade in the heart and liver. |
1(0,0,0,1) | Details |
| 11835623 | Olivier K Jr, Liu J, Pope C: Inhibition of forskolin-stimulated cAMP formation in vitro by paraoxon and chlorpyrifos oxon in cortical slices from neonatal, juvenile, and adult rats. J Biochem Mol Toxicol. 2001;15(5):263-9. Both oxons have also been shown to interact directly with muscarinic receptors coupled to inhibition of adenylyl cyclase. |
1(0,0,0,1) | Details |
| 14754568 | Aldridge JE, Seidler FJ, Slotkin TA: Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling. Environ Health Perspect. 2004 Feb;112(2):148-55. |
0(0,0,0,0) | Details |
| 16256208 | Slotkin TA, Tate CA, Cousins MM, Seidler FJ: Imbalances emerge in cardiac autonomic cell signaling after neonatal exposure to terbutaline or chlorpyrifos, alone or in combination. Brain Res Dev Brain Res. 2005 Dec 7;160(2):219-30. Epub 2005 Oct 26. |
0(0,0,0,0) | Details |
| 10229709 | Slotkin TA: Developmental cholinotoxicants: and chlorpyrifos. . Environ Health Perspect. 1999 Feb;107 Suppl 1:71-80. |
0(0,0,0,0) | Details |
| 15710176 | Meyer A, Seidler FJ, Aldridge JE, Slotkin TA: Developmental exposure to terbutaline alters cell signaling in mature rat brain regions and augments the effects of subsequent neonatal exposure to the organophosphorus insecticide chlorpyrifos. Toxicol Appl Pharmacol. 2005 Mar 1;203(2):154-66. |
0(0,0,0,0) | Details |