| PubMed |
Abstract |
RScore(About this table) |
| 17589599 |
Slotkin TA, Seidler FJ, Fumagalli F: Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily. Environ Health Perspect. 2007 Jun;115(6):909-16. Epub 2007 Feb 27.
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33(0,1,1,3) |
Details |
| 19368821 |
Slotkin TA, Seidler FJ: Protein kinase C is a target for diverse developmental neurotoxicants: transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells. Brain Res. 2009 Mar 31;1263:23-32. Epub 2009 Feb 5.
We compared two organophosphate insecticides (chlorpyrifos, diazinon) with an organochlorine (dieldrin) and a metal (Ni (2+)) for similarities and differences in their effects on gene expression encoding subtypes of protein kinase C and their modulators, a cell signaling cascade that integrates the actions of neurotrophic factors involved in brain development. |
6(0,0,1,1) |
Details |
| 18502319 |
Slotkin TA, Seidler FJ, Fumagalli F: Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro. Brain Res Bull. 2008 Jul 1;76(4):424-38. Epub 2008 Feb 1.
We administered chlorpyrifos and diazinon to neonatal rats on postnatal days 1-4 at doses devoid of systemic toxicity or growth impairment, and spanning the threshold for barely-detectable cholinesterase inhibition. |
5(0,0,0,5) |
Details |