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Guizzetti M, Pathak S, Giordano G, Costa LG: Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation. Toxicology. 2005 Nov 15;215(3):182-90. Epub 2005 Aug 15.
Though little attention has been given to the possibility that glial cells may represent a target for the developmental neurotoxicity of organophosphorus (OP) insecticides, recent evidence, obtained in particular with chlorpyrifos (CP), suggests that developmental exposure to this compound may indeed target astrocytes.
OP insecticides and their oxons were three- to six-fold more potent in inhibiting [(3) H] thymidine incorporation when cells were synchronized in the G (0)/G (1) phase of the cell cycle and re-stimulated by carbachol or epidermal growth factor. |
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