| Name | alpha tubulin |
|---|---|
| Synonyms | Alpha tubulin ubiquitous; Tubulin K alpha 1; Tubulin alpha ubiquitous chain; K alpha 1; K ALPHA 1 protein; alpha tubulin; K alpha 1s; K ALPHA 1 proteins… |
| Name | chlorpyrifos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19632257 | Grigoryan H, Schopfer LM, Peeples ES, Duysen EG, Grigoryan M, Thompson CM, Lockridge O: Mass spectrometry identifies multiple organophosphorylated sites on tubulin. Toxicol Appl Pharmacol. 2009 Oct 15;240(2):149-58. Epub 2009 Jul 24. Chlorpyrifos oxon bound covalently to tyrosines 83, 103, 108, 161, 224, 262, 272, 357, and 399 in bovine alpha tubulin, and to tyrosines 50, 51, 59, 106, 159, 281, 310, and 340 in bovine beta tubulin. |
81(1,1,1,1) | Details |
| 18502412 | Grigoryan H, Schopfer LM, Thompson CM, Terry AV, Masson P, Lockridge O: Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP- to tyrosines on tubulin: a potential mechanism of long term toxicity by organophosphorus agents. Chem Biol Interact. 2008 Sep 25;175(1-3):180-6. Epub 2008 Apr 22. It was found that OP bound to 83 of alpha tubulin in peptide TGTYR, 59 in beta tubulin peptide YVPR, 281 in beta tubulin peptide GSQQYR, and 159 in beta tubulin peptide EEYPDR. |
1(0,0,0,1) | Details |
| 19631231 | Grigoryan H, Lockridge O: Nanoimages show disruption of tubulin polymerization by chlorpyrifos oxon: implications for neurotoxicity. Toxicol Appl Pharmacol. 2009 Oct 15;240(2):143-8. Epub 2009 Jul 22. The two labeled tyrosines in polymerized tubulin were Tyr 103 in EDAANNYR of alpha tubulin, and Tyr 281 in GSQQYR of beta tubulin. |
1(0,0,0,1) | Details |
| 12140181 | Schuh RA, Lein PJ, Beckles RA, Jett DA: Noncholinesterase mechanisms of chlorpyrifos neurotoxicity: altered phosphorylation of Ca2+/cAMP response element binding protein in cultured neurons. Toxicol Appl Pharmacol. 2002 Jul 15;182(2):176-85. Western blot analysis of lysates from primary cultures of cortical neurons exposed to CPF, CPF-oxon, or trichloropyridinol (TCP) for 1 h and cultures exposed to trichloropyridinol (TCP) for 7 days indicated that all exposures increased the level of the phosphorylated (activated) form of CREB (pCREB), without significant changes in total CREB or alpha-tubulin. |
1(0,0,0,1) | Details |
| 17321052 | Prendergast MA, Self RL, Smith KJ, Ghayoumi L, Mullins MM, Butler TR, Buccafusco JJ, Gearhart DA, Terry AV Jr: Microtubule-associated targets in chlorpyrifos oxon hippocampal neurotoxicity. Neuroscience. 2007 Apr 25;146(1):330-9. Epub 2007 Feb 22. Cytotoxicity (somatic uptake of the non-vital marker propidium iodide), as well as IR of alpha-tubulin and microtubule-associated protein-2 (a/b) [MAP-2], was assessed 1, 3, and 7 days after the start of CPO exposure. |
1(0,0,0,1) | Details |
| 20021063 | Sachana M, Flaskos J, Hargreaves AJ: Effects of Chlorpyrifos and Chlorpyrifos-Methyl on the Outgrowth of Axon-Like Processes, Tubulin, and GAP-43 in N2a Cells. Toxicol Mech Methods. 2005;15(6):405-10. |
0(0,0,0,0) | Details |