Protein Information

Name cytochrome P450 monooxygenases
Synonyms CYP M; CYP20A1; CYP20A1 protein; Cytochrome P450 family 20 subfamily A polypeptide 1; Cytochrome P450 monooxygenase; CYP20A1 proteins; Cytochrome P450 family 20 subfamily A polypeptide 1s; Cytochrome P450 monooxygenases

Compound Information

Name chlorpyrifos
CAS

Reference List

PubMed Abstract RScore(About this table)
18615705 Yang ML, Zhang JZ, Zhu KY, Xuan T, Liu XJ, Guo YP, Ma EB: Mechanisms of organophosphate resistance in a field population of oriental migratory locust, Locusta migratoria manilensis (Meyen). Arch Insect Biochem Physiol. 2009 May;71(1):3-15.

The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists [triphenyl phosphate (TPP), piperonyl butoxide (PBO), and diethyl maleate (DEM)], activities of major detoxification enzymes [general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)], and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen).
31(0,1,1,1) Details
16865602 Rakotondravelo ML, Anderson TD, Charlton RE, Zhu KY: Sublethal effects of three pesticides on activities of selected target and detoxification enzymes in the aquatic midge, Chironomus tentans (diptera: chironomidae). Arch Environ Contam Toxicol. 2006 Oct;51(3):360-6. Epub 2006 Jul 21.

Sublethal effects of three pesticides including atrazine (triazine herbicide), DDT (organochlorinated insecticide), and chlorpyrifos (organophosphate insecticide) on acetylcholinesterase (AChE), general esterase (GE), glutathione S-transferase (GST), and cytochrome P450 monooxygenase (P450) activities were evaluated in the aquatic midge Chironomus tentans.
6(0,0,1,1) Details
19937914 Feng Y, Wu Q, Wang S, Chang X, Xie W, Xu B, Zhang Y: Cross-resistance study and biochemical mechanisms of thiamethoxam resistance in B-biotype Bemisia tabaci (Hemiptera: Aleyrodidae). Pest Manag Sci. 2010 Mar;66(3):313-8.

No cross-resistance to fipronil, chlorpyrifos or deltamethrin was seen.
Biochemical assays showed that cytochrome P450 monooxygenase activities increased 1.21- and 1.68-fold respectively, and carboxylesterase activity increased 2.96-fold in the TH-R strain.
2(0,0,0,2) Details
11425027 Lee SE, Lees EM: Biochemical mechanisms of resistance in strains of Oryzaephilus surinamensis (Coleoptera: Silvanidae) resistant to malathion and chlorpyrifos-methyl. J Econ Entomol. 2001 Jun;94(3):706-13.

The acetylcholinesterase, carboxylesterase, and cytochrome P450 monooxygenase activities of three strains of Oryzaephilus srinamensis (L.) were examined to better understand biochemical mechanisms of resistance.
2(0,0,0,2) Details
10504896 Scharf ME, Lee CY, Neal JJ, Bennett GW: Cytochrome P450 MA expression in insecticide-resistant German cockroaches (Dictyoptera: Blattellidae). J Econ Entomol. 1999 Aug;92(4):788-93.

Cytochrome P450 monooxygenases are detoxification enzymes commonly involved in insecticide resistance by insects.
Strains showing the highest P450 MA expression had both the highest tolerance to the organophosphate insecticide chlorpyrifos and cytochrome P450-mediated demethylation activity.
1(0,0,0,1) Details
17173346 Bielza P, Espinosa PJ, Quinto V, Abellan J, Contreras J: Synergism studies with binary mixtures of pyrethroid, carbamate and organophosphate insecticides on Frankliniella occidentalis (Pergande). Pest Manag Sci. 2007 Jan;63(1):84-9.

The major mechanism of resistance to most insecticides in Frankliniella occidentalis (Pergande) is metabolic, piperonyl butoxide (PBO) suppressible, mediated by cytochrome-P450 monooxygenases and conferring cross-resistance among insecticide classes.
The efficacy of insecticide mixtures of acrinathrin, methiocarb, formetanate and chlorpyrifos was studied by topical exposure in strains of F. occidentalis selected for resistance to each insecticide.
1(0,0,0,1) Details
16190164 Rose RL, Tang J, Choi J, Cao Y, Usmani A, Cherrington N, Hodgson E: Pesticide metabolism in humans, including polymorphisms. Scand J Work Environ Health. 2005;31 Suppl 1:156-63; discussion 119-22.

Pesticides examined using human liver microsomes and cytosolic fractions included chlorpyrifos, carbaryl and permethrin.
The metabolic pathways involved include cytochrome P450 monooxygenases (CYP), esterases, and alcohol and aldehyde dehydrogenases.
1(0,0,0,1) Details