Protein Information

Name PN5
Synonyms NAV1.9; Na(V)1.9; PN5; Peripheral nerve sodium channel 5; SCN11A; SCN12A; SNS 2; SNS2…

Compound Information

Name chlorpyrifos
CAS

Reference List

PubMed Abstract RScore(About this table)
10876030 Dam K, Seidler FJ, Slotkin TA: Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity. Brain Res Dev Brain Res. 2000 Jun 30;121(2):179-87.

Administration of 1 mg/kg s.c. of chlorpyrifos on postnatal (PN) days 1-4 elicited deficits in reflex righting on PN3-4 and in geotaxic responses on PN5-8, an effect that was specific to females.
6(0,0,1,1) Details
11882345 Garcia SJ, Seidler FJ, Qiao D, Slotkin TA: Chlorpyrifos targets developing glia: effects on glial fibrillary acidic protein. Brain Res Dev Brain Res. 2002 Feb 28;133(2):151-61.

Early postnatal (PN) CPF treatment (PN1-4) elicited effects only in the cerebellum of male rats; GFAP was suppressed initially (PN5) and showed a rebound elevation (PN10) before returning to normal values by PN30.
1(0,0,0,1) Details
11557094 Raines KW, Seidler FJ, Slotkin TA: Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos. Brain Res Dev Brain Res. 2001 Sep 23;130(1):65-72.

At the end of the treatment period (PN5 and 15, respectively) and 5-7 days later, we then examined the effects on paroxetine (PXT) binding to the presynaptic 5HT high-affinity transporter, a marker for serotonin (5HT) projections.
1(0,0,0,1) Details
10837889 Auman JT, Seidler FJ, Slotkin TA: Neonatal chlorpyrifos exposure targets multiple proteins governing the hepatic adenylyl cyclase signaling cascade: implications for neurotoxicity. Brain Res Dev Brain Res. 2000 May 11;121(1):19-27.

On PN5, 24 h after the last dose, AC catalytic activity was induced as assessed by the response to the direct AC stimulant, Mn (2+).
1(0,0,0,1) Details
11675126 Navarro HA, Basta PV, Seidler FJ, Slotkin TA: Neonatal chlorpyrifos administration elicits deficits in immune function in adulthood: a neural effect?. Brain Res Dev Brain Res. 2001 Oct 24;130(2):249-52.

0(0,0,0,0) Details