| Name | choline transporter |
|---|---|
| Synonyms | CHT; CHT 1; CHT1; Choline transporter; Hemicholinium 3 sensitive choline transporter; High affinity choline transporter 1; SLC5A7; Solute carrier family 5 member 7… |
| Name | chlorpyrifos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18941570 | Slotkin TA, Bodwell BE, Ryde IT, Levin ED, Seidler FJ: Exposure of neonatal rats to parathion elicits sex-selective impairment of systems in brain regions during adolescence and adulthood. Environ Health Perspect. 2008 Oct;116(10):1308-14. Epub 2008 May 19. METHODS: We assessed neurochemical indices related to the function of synapses (choline acetyltransferase, presynaptic high-affinity choline transporter, nicotinic cholinergic receptors) in brain regions comprising all the major projections, with determinations carried out from adolescence to adulthood (PNDs 30, 60, and 100). Superimposed on this general pattern, the cerebrocortical effects showed a nonmonotonic dose-response relationship, with regression of the defects at the higher parathion dose; this relationship has been seen also after comparable treatments with chlorpyrifos and diazinon and likely represents the involvement of cholinesterase-related actions that mask or offset the effects of lower doses. |
1(0,0,0,1) | Details |
| 17548533 | Terry AV Jr, Gearhart DA, Beck WD Jr, Truan JN, Middlemore ML, Williamson LN, Bartlett MG, Prendergast MA, Sickles DW, Buccafusco JJ: Chronic, intermittent exposure to chlorpyrifos in rats: protracted effects on axonal transport, neurotrophin receptors, cholinergic markers, and information processing. J Pharmacol Exp Ther. 2007 Sep;322(3):1117-28. Epub 2007 Jun 4. Furthermore, the 18.0 mg/kg dose of CPF was associated with (brain region-dependent) decreases in nerve growth factor receptors and cholinergic proteins including the vesicular acetylcholine transporter, the high-affinity choline transporter, and the alpha (7)-nicotinic acetylcholine receptor. |
1(0,0,0,1) | Details |
| 15647600 | Richardson JR, Chambers JE: Effects of repeated oral postnatal exposure to chlorpyrifos on cholinergic neurochemistry in developing rats. Toxicol Sci. 2005 Apr;84(2):352-9. Epub 2005 Jan 12. High-affinity choline transporter levels were decreased at all time points in the high dosage group and on PND 6, 22, and 30 in the low dosage group. |
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| 8937895 | Liu J, Pope CN: Effects of chlorpyrifos on high-affinity uptake and [3H] hemicholinium-3 binding in rat brain. Fundam Appl Toxicol. 1996 Nov;34(1):84-90. High-affinity uptake (HACU, the rate-limiting step in acetlcholine synthesis) and binding to [3H]-hemicholinium-3 (HC-3, a specific ligand for the choline transporter) were chosen as indicators of acetylcholine synthesis. |
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| 14757517 | Qiao D, Seidler FJ, Abreu-Villaca Y, Tate CA, Cousins MM, Slotkin TA: Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood. Brain Res Dev Brain Res. 2004 Jan 31;148(1):43-52. In contrast, hemicholinium-3 (HC-3) binding to the presynaptic choline transporter, an index of nerve impulse activity, was markedly subnormal. |
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| 12676612 | Qiao D, Seidler FJ, Tate CA, Cousins MM, Slotkin TA: Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood. Environ Health Perspect. 2003 Apr;111(4):536-44. In contrast, hemicholinium-3 binding to the presynaptic choline transporter, which is responsive to nerve impulse activity, displayed marked suppression in the animals exposed to CPF; despite a return to nearly normal values by weaning, deficits were again apparent in adolescence and adulthood. |
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| 18335101 | Slotkin TA, Bodwell BE, Levin ED, Seidler FJ: Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and systems. Environ Health Perspect. 2008 Mar;116(3):340-8. The patterns seen here differ substantially from those seen in earlier work with chlorpyrifos, reinforcing the concept that the various organophosphates have fundamentally different effects on the developmental trajectories of specific neurotransmitter systems, unrelated to their shared action as cholinesterase inhibitors. METHODS: We then evaluated the lasting effects on indices of neural cell number and size, and on functional markers of synapses (choline acetyltransferase, presynaptic high-affinity choline transporter, nicotinic cholinergic receptors) in a variety of brain regions. |
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| 18436430 | Slotkin TA, Seidler FJ, Ryde IT, Yanai J: Developmental effects of chlorpyrifos on and pathways in an avian model. Neurotoxicol Teratol. 2008 Sep-Oct;30(5):433-9. Epub 2008 Mar 18. Both doses evoked significant reductions in the presynaptic high-affinity choline transporter, the rate-limiting factor in biosynthesis, as monitored by binding of hemicholinium-3. |
1(0,0,0,1) | Details |
| 16675431 | Slotkin TA, Levin ED, Seidler FJ: Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity. Environ Health Perspect. 2006 May;114(5):746-51. We contrasted neuritic outgrowth and cholinergic synaptic development in neonatal rats given different organophosphates (chlorpyrifos, diazinon, parathion) at doses spanning the threshold for impaired growth and viability. |
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