| Name | protein kinase C (protein family or complex) |
|---|---|
| Synonyms | Protein kinase C; PKC |
| Name | chlorpyrifos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19368821 | Slotkin TA, Seidler FJ: Protein kinase C is a target for diverse developmental neurotoxicants: transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent in PC12 cells. Brain Res. 2009 Mar 31;1263:23-32. Epub 2009 Feb 5. |
87(1,1,2,2) | Details |
| 15470723 | Izrael M, Van der Zee EA, Slotkin TA, Yanai J: Cholinergic synaptic signaling mechanisms underlying behavioral teratogenicity: effects of chlorpyrifos, and heroin converge on protein kinase C translocation in the intermedial part of the hyperstriatum ventrale and on imprinting behavior in an avian model. J Neurosci Res. 2004 Nov 15;78(4):499-507. |
7(0,0,1,2) | Details |
| 9096284 | Bagchi D, Bagchi M, Tang L, Stohs SJ: Comparative in vitro and in vivo protein kinase C activation by selected pesticides and transition metal salts. Toxicol Lett. 1997 Mar 14;91(1):31-7. In the hepatic tissues, the greatest increases in activities were observed with TCDD, chlorpyrifos, endrin and Cd (II), while chlorpyrifos and fenthion exerted the greatest increases in the brain tissues. |
2(0,0,0,2) | Details |
| 15542768 | Yanai J, Beer A, Huleihel R, Izrael M, Katz S, Levi Y, Rozenboim I, Yaniv SP, Slotkin TA: Convergent effects on cell signaling mechanisms mediate the actions of different neurobehavioral teratogens: alterations in cholinergic regulation of protein kinase C in chick and avian models. Ann N Y Acad Sci. 2004 Oct;1025:595-601. Two otherwise unrelated agents that converge on cholinergic systems, chlorpyrifos and elicited the same spectrum of effects on PKC isoforms and imprinting but had more robust actions. |
2(0,0,0,2) | Details |
| 11083088 | Bomser J, Casida JE: Activation of extracellular signal-regulated kinases (ERK 44/42) by chlorpyrifos oxon in Chinese hamster ovary cells. J Biochem Mol Toxicol. 2000;14(6):346-53. ERK 44/42 activation by CPO is insensitive to the protein kinase A inhibitor H-89, but is completely abolished by the phosphatidylinositol 3-kinase (P13-K) inhibitor wortmannin, the protein kinase C (PKC) inhibitor GF-109203X, and the mitogen-activated extracellular signal-regulated protein kinase kinase (MEK) inhibitor PD 098059. |
1(0,0,0,1) | Details |
| 11781077 | Bomser JA, Quistad GB, Casida JE: Chlorpyrifos oxon potentiates diacylglycerol-induced extracellular signal-regulated kinase (ERK 44/42) activation, possibly by diacylglycerol lipase inhibition. Toxicol Appl Pharmacol. 2002 Jan 1;178(1):29-36. This activation is blocked by inhibitors of protein kinase C and mitogen-activated protein kinase kinase, suggesting that these enzymes are important in CPO/DAG cellular signaling. |
1(0,0,0,1) | Details |
| 11485862 | Buznikov GA, Nikitina LA, Bezuglov VV, Lauder JM, Padilla S, Slotkin TA: An invertebrate model of the developmental neurotoxicity of insecticides: effects of chlorpyrifos and dieldrin in sea urchin embryos and larvae. Environ Health Perspect. 2001 Jul;109(7):651-61. Studies with cholinergic receptor blocking agents and protein kinase C inhibitors indicated two distinct types of effects, one mediated through stimulation of nicotinic cholinergic receptors and the other targeting intracellular signaling. |
1(0,0,0,1) | Details |