| Name | hormone receptors |
|---|---|
| Synonyms | Early response protein NAK1; GFRP 1; GFRP1; Growth factor inducible nuclear protein N10; Growth factor response protein 1; HMR; Hormone receptor; N10… |
| Name | chlorpyrifos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9221834 | Song X, Seidler FJ, Saleh JL, Zhang J, Padilla S, Slotkin TA: Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade. Toxicol Appl Pharmacol. 1997 Jul;145(1):158-74. In all three, chlorpyrifos evoked deficits in multiple components of the adenylyl cyclase cascade: expression and activity of adenylyl cyclase itself, functioning of G-proteins that link neurotransmitter and hormone receptors to cyclase activity, and expression of neurotransmitter receptors that act through this cascade. |
81(1,1,1,1) | Details |
| 10806373 | Vinggaard AM, Hnida C, Breinholt V, Larsen JC: Screening of selected pesticides for inhibition of CYP19 aromatase activity in vitro. Toxicol In Vitro. 2000 Jun;14(3):227-34. Many pesticides are able to block or activate the steroid hormone receptors and/or to affect the levels of sex hormones, thereby potentially affecting the development or expression of the male and female reproductive system or both. The compounds, which did not affect the aromatase activity, were bromopropylate, chlorfenvinphos, chlorobenzilate, chlorpyrifos, diuron, heptachlor, iprodion, linuron, pentachlorphenol, procymidon, propyzamide, quintozen, tetrachlorvinphos and tetradifon. |
1(0,0,0,1) | Details |
| 12198127 | Grun F, Venkatesan RN, Tabb MM, Zhou C, Cao J, Hemmati D, Blumberg B: X receptors alpha and beta are pharmacologically distinct and do not function as xenobiotic receptors. J Biol Chem. 2002 Nov 15;277(46):43691-7. Epub 2002 Aug 26. The Xenopus nuclear hormone receptors, BXRalpha and BXRbeta, share 82% identity within their ligand-binding domains and are classified as members of the NR1I2 subfamily that includes the mammalian steroid and xenobiotic receptor, SXR/PXR. Furthermore, BXRalpha-specific agonists such as 4-ABB, chlorpyrifos, and trifluralin act as antagonists on BXRbeta. |
1(0,0,0,1) | Details |