Protein Information

Name hemoglobin (protein family or complex)
Synonyms Hemoglobin; Hemoglobins

Compound Information

Name chlorpyrifos
CAS

Reference List

PubMed Abstract RScore(About this table)
18328532 Ha MH, Choi J: Effects of environmental contaminants on hemoglobin of larvae of aquatic midge, Chironomus riparius (Diptera: Chironomidae): a potential biomarker for ecotoxicity monitoring. Chemosphere. 2008 May;71(10):1928-36. Epub 2008 Mar 6.

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8829340 Willig S, Hunter DL, Dass PD, Padilla S: Validation of the use of 6,6'-dithiodinicotinic acid as a chromogen in the Ellman method for cholinesterase determinations. Vet Hum Toxicol. 1996 Aug;38(4):249-53.


Use of 6,6'-dithiodinicotinic acid (DTNA) might be a solution because, like DTNB, it also is a chromogen for sulfhydryl groups, but with an optimal absorption wavelength of 340 nm (ie removed from the hemoglobin absorbance maximum).
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16624371 Lee SM, Lee SB, Park CH, Choi J: Expression of heat shock protein and hemoglobin genes in Chironomus tentans (Diptera, chironomidae) larvae exposed to various environmental pollutants: a potential biomarker of freshwater monitoring. Chemosphere. 2006 Nov;65(6):1074-81. Epub 2006 Apr 19.

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8642625 Wilson BW, Padilla S, Henderson JD, Brimijoin S, Dass PD, Elliot G, Jaeger B, Lanz D, Pearson R, Spies R: Factors in standardizing automated cholinesterase assays. J Toxicol Environ Health. 1996 Jun 7;48(2):187-95.


The ChE activity in erythrocyte samples differed more between laboratories due to a high blank, low erythrocyte AChE activity and hemoglobin absorption at the wavelength of the assay.
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20329403 Akhtar N, Srivastava MK, Raizada RB: Assessment of chlorpyrifos toxicity on certain organs in rat, Rattus norvegicus. J Environ Biol. 2009 Nov;30(6):1047-53.

There was decrease in RBC counts and levels of hemoglobin (Hb) and hematocrit (HCT) with increase in WBC counts.
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20020991 Giron-Perez MI, Barcelos-Garcia R, Vidal-Chavez ZG, Romero-Banuelos CA, Robledo-Marenco ML: Effect of Chlorpyrifos on the Hematology and Phagocytic Activity of Nile Tilapia Cells (Oreochromis niloticus). Toxicol Mech Methods. 2006;16(9):495-9.

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