| Name | neurotoxic esterase |
|---|---|
| Synonyms | NTE; SWS; Neuropathy target esterase; Neurotoxic esterase; PNPLA 6; patatin like phospholipase domain containing 6; Neuropathy target esterases… |
| Name | chlorpyrifos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9788582 | Li W, Casida JE: Organophosphorus neuropathy target esterase inhibitors selectively block outgrowth of neurite-like and cell processes in cultured cells. Toxicol Lett. 1998 Sep 15;98(3):139-46. This study compares two direct-acting neuropathy target esterase (NTE) inhibitors (mipafox and 2-octyl-4H-1,3,2-benzodioxophosphorin 2-oxide (OBDPO)), a metabolic precursor to an NTE inhibitor (tri-o-cresyl or TOCP) and a potent acetylcholinesterase inhibitor (chlorpyrifos oxon or CPO) for their effects on outgrowth of neurite-like and cell processes and on viability in differentiated cultured cells (rat adrenal pheochromocytoma (PC-12) and brain glial tumor (C6)). |
32(0,1,1,2) | Details |
| 12791540 | Kropp TJ, Richardson RJ: Relative inhibitory potencies of chlorpyrifos oxon, chlorpyrifos methyl oxon, and mipafox for acetylcholinesterase versus neuropathy target esterase. J Toxicol Environ Health A. 2003 Jun 27;66(12):1145-57. |
32(0,1,1,2) | Details |
| 7684990 | Richardson RJ, Moore TB, Kayyali US, Fowke JH, Randall JC: Inhibition of hen brain acetylcholinesterase and neurotoxic esterase by chlorpyrifos in vivo and kinetics of inhibition by chlorpyrifos oxon in vitro: application to assessment of neuropathic risk. Fundam Appl Toxicol. 1993 Apr;20(3):273-9. |
32(0,1,1,2) | Details |
| 7689993 | Richardson RJ, Moore TB, Kayyali US, Randall JC: Chlorpyrifos: assessment of potential for delayed neurotoxicity by repeated dosing in adult hens with monitoring of brain acetylcholinesterase, brain and lymphocyte neurotoxic esterase, and plasma butyrylcholinesterase activities. Fundam Appl Toxicol. 1993 Jul;21(1):89-96. Previous work has shown that acute exposures to chlorpyrifos (CPS; diethyl 3,5,6-trichloro-2-pyridyl phosphorothionate) cannot produce > 70% inhibition of brain neurotoxic esterase (NTE) and cause organophosphorus compound-induced delayed neurotoxicity (OPIDN) unless the dose is well in excess of the LD50, necessitating aggressive therapy for cholinergic toxicity. |
87(1,1,2,2) | Details |
| 1282230 | Fikes JD, Zachary JF, Parker AJ, Beasley VR: Clinical, biochemical, electrophysiologic, and histologic assessment of chlorpyrifos induced delayed neuropathy in the cat. Neurotoxicology. 1992 Fall;13(3):663-78. The ability of a supralethal dose of chlorpyrifos to produce delayed neuropathy was examined using assessments of clinical signs, electromyography (EMG), motor nerve conduction velocity (MNCV), lymphocyte neuropathy target esterase activity (LNTE), and histologic changes in nervous system tissues. |
6(0,0,1,1) | Details |
| 9268605 | Ehrich M, Correll L, Veronesi B: Acetylcholinesterase and neuropathy target esterase inhibitions in neuroblastoma cells to distinguish organophosphorus compounds causing acute and delayed neurotoxicity. Fundam Appl Toxicol. 1997 Jul;38(1):55-63. Inhibition of AChE was greater than inhibition of NTE, without overlap of the concentration-response curves, for OPs which are more likely to cause acute, rather than delayed, effects in vivo (e.g., chlorpyrifos-oxon, dichlorvos, and trichlorfon). |
2(0,0,0,2) | Details |
| 7531775 | Richardson RJ: Assessment of the potential of chlorpyrifos relative to other organophosphorus compounds: a critical review of the literature. J Toxicol Environ Health. 1995 Feb;44(2):135-65. Because chlorpyrifos and other OP insecticides are designed to produce acute cholinergic effects through inhibition of acetylcholinesterase (AChE) and some OP compounds can cause OP compound-induced delayed neurotoxicity (OPIDN) via chemical modification of neurotoxic esterase (neuropathy target esterase, NTE), this review focuses on the capacity of chlorpyrifos to precipitate these and other adverse neurological consequences. |
31(0,1,1,1) | Details |
| 15805077 | Jortner BS, Hancock SK, Hinckley J, Flory L, Tobias L, Williams L, Ehrich M: Neuropathological studies of rats following multiple exposure to tri-ortho-tolyl chlorpyrifos and stress. Toxicol Pathol. 2005;33(3):378-85. There was association of this lesion with inhibition of the enzyme neurotoxic esterase in hippocampal tissue from TOTP-treated rats. |
1(0,0,0,1) | Details |
| 18495101 | Casida JE, Nomura DK, Vose SC, Fujioka K: Organophosphate-sensitive lipases modulate brain lysophospholipids, ether lipids and endocannabinoids. Chem Biol Interact. 2008 Sep 25;175(1-3):355-64. Epub 2008 May 20. It is also a detoxifying enzyme that hydrolyzes chlorpyrifos oxon (CPO) and some other potent insecticide metabolites. Neuropathy target esterase (NTE) hydrolyzes lysophosphatidylcholine (lysoPC) as a preferred substrate. |
1(0,0,0,1) | Details |
| 16243304 | Casida JE, Quistad GB: Serine hydrolase targets of organophosphorus toxicants. Chem Biol Interact. 2005 Dec 15;157-158:277-83. Epub 2005 Oct 21. The toxicological relevance of known secondary OP targets is established mainly from observations with humans (butyrylcholinesterase and neuropathy target esterase-lysophospholipase) and studies with mice (cannabinoid CB1 receptor, carboxylesterase, lysophospholipase and platelet activating factor acetylhydrolase) and hen eggs (arylformamidase or kynurenine formamidase). Pesticides most commonly shown to inhibit these targets in experimental vertebrates are chlorpyrifos and tribufos. |
1(0,0,0,1) | Details |
| 11718958 | Dyer SM, Cattani M, Pisaniello DL, Williams FM, Edwards JW: Peripheral cholinesterase inhibition by occupational chlorpyrifos exposure in Australian termiticide applicators. Toxicology. 2001 Dec 28;169(3):177-85. Lymphocyte neuropathy target esterase (NTE) is thought to have potential as a predictor of organophosphate-induced delayed neuropathy (OPIDN). |
1(0,0,0,1) | Details |
| 10561082 | Quistad GB, Casida JE: Sensitivity of blood-clotting factors and digestive enzymes to inhibition by organophosphorus pesticides. J Biochem Mol Toxicol. 2000;14(1):51-6. Organophosphorus pesticide toxicology is normally evaluated in relation to inhibition of cholinesterases (acetyl and butyryl), neuropathy target esterase, and carboxylesterases, with less attention given to other physiologically important hydrolases. Inhibitors that we examined are organophosphorus insecticides or their activated metabolites (paraoxon, chlorpyrifos oxon, and profenofos) and other toxicants (phenyl saligenin cyclic phosphonate and tribufos) for comparison with values that are found in the literature for the fluorophosphonates (isoflurophate and sarin). |
2(0,0,0,2) | Details |
| 14718179 | Ehrich M, Hancock S, Ward D, Holladay S, Pung T, Flory L, Hinckley J, Jortner BS: Neurologic and immunologic effects of exposure to chlorpyrifos, and multiple doses of tri-ortho-tolyl over a 28-day period in rats. J Toxicol Environ Health A. 2004 Mar 12;67(5):431-57. At the end of the 28-d testing period, rats were sacrificed and activities of cholinesterase, neurotoxic esterase (neuropathy target esterase), and/or carboxylesterase were evaluated in blood, liver, and/or brain regions (basal forebrain, caudate putamen, cerebral cortex, hippocampus). |
1(0,0,0,1) | Details |
| 11566565 | Sachana M, Flaskos J, Alexaki E, Glynn P, Hargreaves AJ: The toxicity of chlorpyrifos towards differentiating mouse N2a neuroblastoma cells. Toxicol In Vitro. 2001 Aug-Oct;15(4-5):369-72. |
0(0,0,0,0) | Details |
| 11690566 | Barber DS, Ehrich M: Esterase inhibition in SH-SY5Y human neuroblastoma cells following exposure to organophosphorus compounds for 28 days. In Vitr Mol Toxicol. 2001 Summer;14(2):129-35. To examine metabolic activation in these exposures, pairs of pro- and active toxicants were studied, including chlorpyrifos and its oxon, parathion and paraoxon, and tri-ortho-tolyl and phenyl saligenin phospahte. |
0(0,0,0,0) | Details |
| 11350214 | Quistad GB, Sparks SE, Casida JE: Fatty acid amide hydrolase inhibition by organophosphorus pesticides. Toxicol Appl Pharmacol. 2001 May 15;173(1):48-55. Chlorpyrifos oxon inhibits 50% of the FAAH activity (IC50 at 15 min, 25 degrees C, pH 9.0) in vitro at 40--56 nM for mouse brain and liver, whereas methyl arachidonyl phosphonofluoridate, ethyl octylphosphonofluoridate (EOPF), oleyl-4H-1,3,2-benzodioxaphosphorin 2-oxide (oleyl-BDPO), and dodecyl-BDPO give IC50s of 0.08--1.1 nM. |
0(0,0,0,0) | Details |
| 16042503 | Lotti M, Moretto A: Organophosphate-induced delayed polyneuropathy. . Toxicol Rev. 2005;24(1):37-49. Neuropathy target esterase (NTE) is thought to be the target of OPIDP initiation. In this article, we mainly discuss OP pesticide poisoning, particularly when caused by chlorpyrifos, dichlorvos, isofenphos, methamidophos, mipafox, trichlorfon, trichlornat, phosphamidon/mevinphos and by certain carbamates. |
1(0,0,0,1) | Details |