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Casida JE, Quistad GB: Serine hydrolase targets of organophosphorus toxicants. Chem Biol Interact. 2005 Dec 15;157-158:277-83. Epub 2005 Oct 21.
The toxicological relevance of known secondary OP targets is established mainly from observations with humans (butyrylcholinesterase and neuropathy target esterase-lysophospholipase) and studies with mice (cannabinoid CB1 receptor, carboxylesterase, lysophospholipase and platelet activating factor acetylhydrolase) and hen eggs (arylformamidase or kynurenine formamidase).
Pesticides most commonly shown to inhibit these targets in experimental vertebrates are chlorpyrifos and tribufos. |
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