| Name | vesicular acetylcholine transporter |
|---|---|
| Synonyms | SLC18A3; Solute carrier family 18 member 3; VACHT; Vesicular acetylcholine transporter; Solute carrier family 18 member 3s; Vesicular acetylcholine transporters |
| Name | chlorpyrifos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15647600 | Richardson JR, Chambers JE: Effects of repeated oral postnatal exposure to chlorpyrifos on cholinergic neurochemistry in developing rats. Toxicol Sci. 2005 Apr;84(2):352-9. Epub 2005 Jan 12. On PND 30 choline acetyltransferase activity and vesicular acetylcholine transporter levels were decreased by 12 and 22%, respectively, only in the high dosage group. |
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| 17548533 | Terry AV Jr, Gearhart DA, Beck WD Jr, Truan JN, Middlemore ML, Williamson LN, Bartlett MG, Prendergast MA, Sickles DW, Buccafusco JJ: Chronic, intermittent exposure to chlorpyrifos in rats: protracted effects on axonal transport, neurotrophin receptors, cholinergic markers, and information processing. J Pharmacol Exp Ther. 2007 Sep;322(3):1117-28. Epub 2007 Jun 4. Furthermore, the 18.0 mg/kg dose of CPF was associated with (brain region-dependent) decreases in nerve growth factor receptors and cholinergic proteins including the vesicular acetylcholine transporter, the high-affinity choline transporter, and the alpha (7)-nicotinic acetylcholine receptor. |
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| 14600274 | Richardson JR, Chambers JE: Neurochemical effects of repeated gestational exposure to chlorpyrifos in developing rats. Toxicol Sci. 2004 Jan;77(1):83-90. Epub 2003 Nov 4. Pups were euthanized on postnatal days (PND) 1, 3, 6, 9, 12, and 30 for the determination of brain cholinesterase (ChE) and choline acetyltransferase (ChAT) activities, along with muscarinic receptor (mAChR) densities, the levels of the high-affinity uptake (HACU) system, and the vesicular acetylcholine transporter (VAChT). |
1(0,0,0,1) | Details |