| Name | Fatty acid amide hydrolase |
|---|---|
| Synonyms | Anandamide amidohydrolase; FAAH; Fatty acid amide hydrolase; Oleamide hydrolase; Oleamide hydrolase Anandamide amidohydrolase FAAH; Fatty acid amide hydrolases; Oleamide hydrolases; Oleamide hydrolase Anandamide amidohydrolase FAAHs |
| Name | chlorpyrifos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16310817 | Quistad GB, Klintenberg R, Caboni P, Liang SN, Casida JE: Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice. Toxicol Appl Pharmacol. 2006 Feb 15;211(1):78-83. Epub 2005 Nov 28. Three components of the cannabinoid system are sensitive to selected organophosphorus (OP) compounds: monoacylglycerol (MAG) lipase that hydrolyzes the major endogenous agonist 2-arachidonoylglycerol (2-AG); fatty acid amide hydrolase (FAAH) that cleaves the agonist present in smaller amounts; the CB1 receptor itself. Remarkably high potency and low selectivity is observed with three O-alkyl (C1, C2, C3) alkylphosphonofluoridates (C8, C12) (IC50 0.60-3.0 nM), five S-alkyl (C5, C7, C9) and alkyl (C10, C12) benzodioxaphosphorin oxides (IC50 0.15-5.7 nM) and one OP insecticide metabolite (chlorpyrifos oxon, IC50 34-40 nM). |
2(0,0,0,2) | Details |
| 11350214 | Quistad GB, Sparks SE, Casida JE: Fatty acid amide hydrolase inhibition by organophosphorus pesticides. Toxicol Appl Pharmacol. 2001 May 15;173(1):48-55. Chlorpyrifos oxon inhibits 50% of the FAAH activity (IC50 at 15 min, 25 degrees C, pH 9.0) in vitro at 40--56 nM for mouse brain and liver, whereas methyl arachidonyl phosphonofluoridate, ethyl octylphosphonofluoridate (EOPF), oleyl-4H-1,3,2-benzodioxaphosphorin 2-oxide (oleyl-BDPO), and dodecyl-BDPO give IC50s of 0.08--1.1 nM. |
119(1,2,2,9) | Details |
| 18495101 | Casida JE, Nomura DK, Vose SC, Fujioka K: Organophosphate-sensitive lipases modulate brain lysophospholipids, ether lipids and endocannabinoids. Chem Biol Interact. 2008 Sep 25;175(1-3):355-64. Epub 2008 May 20. It is also a detoxifying enzyme that hydrolyzes chlorpyrifos oxon (CPO) and some other potent insecticide metabolites. Monoacylglycerol lipase and fatty acid amide hydrolase regulate endocannabinoid levels with roles in motility, pain and memory. |
1(0,0,0,1) | Details |