| 20026089 |
Adigun AA, Seidler FJ, Slotkin TA: Disparate developmental neurotoxicants converge on the cyclic AMP signaling cascade, revealed by transcriptional profiles in vitro and in vivo. Brain Res. 2010 Feb 26;1316:1-16. Epub 2009 Dec 21.
We compared organophosphates (chlorpyrifos, diazinon), an organochlorine (dieldrin) and a metal (Ni (2+)) for their effects on neuronotypic PC12 cells, assessing gene transcription involved in the cyclic AMP pathway.
Each agent was introduced during neurodifferentiation at a concentration of 30 microM for 24 or 72 h and we assessed 69 genes encoding adenylyl cyclase isoforms and regulators, G-protein alpha-and beta,gamma-subunits, protein kinase A subtypes and the phosphodiesterase family. |
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