| Name | Egasyn |
|---|---|
| Synonyms | ACAT; Cholesteryl ester hydrolase; CES1; SES 1; SES1; ANAE; Acid esterase; Acyl coenzyme A cholesterol acyltransferase… |
| Name | chlorpyrifos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16011852 | Wheelock CE, Eder KJ, Werner I, Huang H, Jones PD, Brammell BF, Elskus AA, Hammock BD: Individual variability in esterase activity and CYP1A levels in Chinook salmon (Oncorhynchus tshawytscha) exposed to esfenvalerate and chlorpyrifos. Aquat Toxicol. 2005 Aug 30;74(2):172-92. In contrast, liver carboxylesterase activity was significantly inhibited at both the low and high chlorpyrifos dose exposure (56% and 79% inhibition, respectively), while esfenvalerate exposure still had little effect. |
81(1,1,1,1) | Details |
| 18762277 | Crow JA, Middleton BL, Borazjani A, Hatfield MJ, Potter PM, Ross MK: Inhibition of carboxylesterase 1 is associated with ester retention in human THP-1 monocyte/macrophages. Biochim Biophys Acta. 2008 Oct;1781(10):643-54. Epub 2008 Aug 5. Here, we show that CES1 protein is robustly expressed in human THP-1 monocytes/macrophages and its biochemical activity inhibited following treatment of cell lysates and intact cells with chlorpyrifos oxon, paraoxon, or methyl paraoxon (with nanomolar IC (50) values) or after immunodepletion of CES1 protein. |
36(0,1,1,6) | Details |
| 15896444 | Pope CN, Karanth S, Liu J, Yan B: Comparative carboxylesterase activities in infant and adult liver and their in vitro sensitivity to chlorpyrifos oxon. Regul Toxicol Pharmacol. 2005 Jun;42(1):64-9. Epub 2005 Feb 24. Little information is available, however, on the maturational expression of liver carboxylesterases in humans. |
3(0,0,0,3) | Details |
| 12521672 | Richardson J, Chambers J: Effects of gestational exposure to chlorpyrifos on postnatal central and peripheral cholinergic neurochemistry. J Toxicol Environ Health A. 2003 Feb 14;66(3):275-89. Pups were sacrificed on postnatal days 1, 3, 6, 9, and 12 for the determination of brain, heart, lung, and serum cholinesterase, and brain choline acetyltransferase activities, along with liver carboxylesterase activity. |
2(0,0,0,2) | Details |
| 16004201 | Fujikawa Y, Satoh T, Suganuma A, Suzuki S, Niikura Y, Yui S, Yamaura Y: Extremely sensitive biomarker of acute organophosphorus insecticide exposure. Hum Exp Toxicol. 2005 Jun;24(6):333-6. Egasyn-beta-glucuronidase complex is located at the luminal site of liver microsomal endoplasmic reticulum. Thus, the single administration of EPN (O-ethyl O-p-nitrophenylphenylphosphonothioate), acephate and chlorpyrifos increased plasma BG activity in approximately 100-fold the control level in rats. |
2(0,0,0,2) | Details |
| 10543028 | Tang J, Carr RL, Chambers JE: Changes in rat brain cholinesterase activity and muscarinic receptor density during and after repeated oral exposure to chlorpyrifos in early postnatal development. Toxicol Sci. 1999 Oct;51(2):265-72. Brain ChE inhibition in pups was less severe than in dams, whereas liver carboxylesterase (CbxE) inhibition in pups was at the same level as in dams. |
1(0,0,0,1) | Details |
| 17442360 | Crow JA, Borazjani A, Potter PM, Ross MK: Hydrolysis of pyrethroids by human and rat tissues: examination of intestinal, liver and serum carboxylesterases. Toxicol Appl Pharmacol. 2007 May 15;221(1):1-12. Epub 2007 Mar 12. Moreover, a 6-fold interindividual variation in carboxylesterase 1 protein expression in human hepatic cytosols was observed. |
1(0,0,0,1) | Details |
| 15081265 | Karanth S, Liu J, Olivier K Jr, Pope C: Interactive toxicity of the organophosphorus insecticides chlorpyrifos and methyl parathion in adult rats. Toxicol Appl Pharmacol. 2004 Apr 15;196(2):183-90. |
0(0,0,0,0) | Details |