| Name | albumin |
|---|---|
| Synonyms | ALB; Albumin; PRO0883; PRO0903; PRO1341; PRO1708; PRO2044; PRO2619… |
| Name | chlorpyrifos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15525694 | Peeples ES, Schopfer LM, Duysen EG, Spaulding R, Voelker T, Thompson CM, Lockridge O: Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry. Toxicol Sci. 2005 Feb;83(2):303-12. Epub 2004 Nov 3. In vitro experiments with human plasma showed that chlorpyrifos oxon, echothiophate, malaoxon, paraoxon, methyl paraoxon, diazoxon, diisopropylfluorophosphate, and dichlorvos competed with FP- for binding to human albumin. |
86(1,1,1,6) | Details |
| 17188226 | Li B, Schopfer LM, Hinrichs SH, Masson P, Lockridge O: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411. Anal Biochem. 2007 Feb 15;361(2):263-72. Epub 2006 Dec 4. Our goal was to determine whether chlorpyrifos oxon, dichlorvos, diisopropylfluorophosphate (DFP), and sarin covalently bind to human albumin. |
86(1,1,1,6) | Details |
| 18707141 | Ding SJ, Carr J, Carlson JE, Tong L, Xue W, Li Y, Schopfer LM, Li B, Nachon F, Asojo O, Thompson CM, Hinrichs SH, Masson P, Lockridge O: Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP- Chem Res Toxicol. 2008 Sep;21(9):1787-94. Epub 2008 Aug 16. 411 of human albumin is an established site for covalent attachment of 10-fluoroethoxyphosphinyl- N-biotinamidopentyldecanamide (FP- diisopropylfluorophosphate, chlorpyrifos oxon, soman, sarin, and dichlorvos. |
47(0,1,3,7) | Details |
| 18577514 | Lockridge O, Xue W, Gaydess A, Grigoryan H, Ding SJ, Schopfer LM, Hinrichs SH, Masson P: Pseudo-esterase activity of human albumin: slow turnover on 411 and stable acetylation of 82 residues including 59 lysines. J Biol Chem. 2008 Aug 15;283(33):22582-90. Epub 2008 Jun 24. When Tyr-411 was blocked with diisopropylfluorophosphate or chlorpyrifos oxon, albumin had normal esterase activity with beta-naphthyl as visualized on a nondenaturing gel. |
34(0,1,1,4) | Details |
| 18597495 | Sogorb MA, Garcia-Arguelles S, Carrera V, Vilanova E: Serum albumin is as efficient as paraxonase in the detoxication of paraoxon at toxicologically relevant concentrations. Chem Res Toxicol. 2008 Aug;21(8):1524-9. Epub 2008 Jul 3. However, paraoxonase activity associated with lipoprotein was more effective than paraoxonase activity associated with albumin at toxicologically relevant chlorpyrifos-oxon concentrations. |
7(0,0,1,2) | Details |
| 11673119 | Qiao D, Seidler FJ, Slotkin TA: Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells. Environ Health Perspect. 2001 Sep;109(9):909-13. We also found that the addition of sera protected the cells from the adverse effects of chlorpyrifos and that the effect could be reproduced by addition of albumin. |
6(0,0,1,1) | Details |
| 19575182 | Noort D, Hulst AG, van Zuylen A, van Rijssel E, van der Schans MJ: Covalent binding of organophosphorothioates to albumin: a new perspective for OP-pesticide biomonitoring?. Arch Toxicol. 2009 Nov;83(11):1031-6. Epub 2009 Jul 4. In vitro exposure levels of parathion and chlorpyrifos down to 1 microM could readily be assessed. |
4(0,0,0,4) | Details |
| 20020887 | Geter DR, Kan HL, Lowe ER, Rick DL, Charles GD, Gollapudi BB, Mattsson JL: Investigations of oxidative stress, antioxidant response, and protein binding in chlorpyrifos exposed rat neuronal PC12 cells. Toxicol Mech Methods. 2008;18(1):17-23. Examinations into CPF-albumin binding were also conducted. |
2(0,0,0,2) | Details |
| 20211614 | Sogorb MA, Vilanova E: Serum albumins and detoxication of anti-cholinesterase agents. Chem Biol Interact. 2010 Mar 6. Serum albumin displays an esterase activity that is capable of hydrolysing the anti-cholinesterase compounds carbaryl, paraoxon, chlorpyrifos-oxon, diazoxon and O-hexyl, O-2,5-dichlorphenyl phosphoramidate. |
2(0,0,0,2) | Details |
| 18655824 | Heilmair R, Eyer F, Eyer P: Enzyme-based assay for quantification of chlorpyrifos oxon in human plasma. Toxicol Lett. 2008 Sep;181(1):19-24. Epub 2008 Jul 5. The new procedure enabled the assessment of the extent of reversible binding of CPO to human albumin, amounting to 85% under physiological conditions. |
1(0,0,0,1) | Details |
| 17615116 | Carter WG, Tarhoni M, Rathbone AJ, Ray DE: Differential protein adduction by seven organophosphorus pesticides in both brain and thymus. Hum Exp Toxicol. 2007 Apr;26(4):347-53. We found significant adduction of partially characterized protein targets in both rat brain and thymus by azamethiphos, chlorfenvinphos, chlorpyrifos-oxon, diazinon-oxon, dichlorvos and malaoxon, in vitro and pirimiphos-methyl in vivo. However, some adducted proteins are also expressed in blood, notably albumin, and so may provide exposure measures to increase the power of future epidemiological studies. |
1(0,0,0,1) | Details |
| 18930948 | Li B, Schopfer LM, Grigoryan H, Thompson CM, Hinrichs SH, Masson P, Lockridge O: Tyrosines of human and mouse transferrin covalently labeled by organophosphorus agents: a new motif for binding to proteins that have no active site serine. Toxicol Sci. 2009 Jan;107(1):144-55. Epub 2008 Oct 16. However, transferrin, a protein with no active site serine, was covalently modified in vitro by 0.5mM 10-fluoroethoxyphosphinyl-N-biotinamido pentyldecanamide, chlorpyrifos oxon, diisopropylfluorophosphate, dichlorvos, sarin, and soman. These results, together with our previous demonstration that albumin and tubulin bind OP on lead to the conclusion that OP bind covalently to and that OP binding to is a new OP-binding residue. |
1(0,0,0,1) | Details |
| 16447452 | Xie H, Zhu LS, Wang J, Wang XG, Liu W, Qian B, Wang Q: [Enzymatic degradation of organophosphorus insecticide chlorpyrifos by fungus WZ-I]. Huan Jing Ke Xue. 2005 Nov;26(6):164-8. The solubility protein of the crude enzyme was determined with Albumin (bovine serum) as standard protein and the solubility protein of the crude enzyme was 3.36 mg x mL (-1). |
1(0,0,0,1) | Details |
| 17980473 | Ncibi S, Ben Othman M, Akacha A, Krifi MN, Zourgui L: Opuntia ficus indica extract protects against chlorpyrifos-induced damage on mice liver. Food Chem Toxicol. 2008 Feb;46(2):797-802. Epub 2007 Sep 14. Liver damage was evaluated by the measure of its weight and the quantification of some biochemical parameters, such as amino transferase (ALAT), amino transferase (ASAT), phosphatase alkaline (PAL), lactate dehydrogenase (LDH), and albumin in serum by spectrophotometric techniques. |
1(0,0,0,1) | Details |
| 18484351 | Tarhoni MH, Lister T, Ray DE, Carter WG: Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides. Biomarkers. 2008 Jun;13(4):343-63. At pesticide exposures producing approximately 30% inhibition of AChE, rat plasma albumin binding in vitro by azamethiphos (oxon), chlorfenvinphos (oxon), chlorpyrifos-oxon, diazinon-oxon and malaoxon was reduced from controls by 9+/-1%, 67+/-2%, 56+/-2%, 54+/-2% and 8+/-1%, respectively. |
90(1,1,1,10) | Details |