| Name | glial fibrillary acidic protein |
|---|---|
| Synonyms | GFAP; Glial fibrillary acidic protein; Glial fibrillary acidic proteins |
| Name | chlorpyrifos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11882345 | Garcia SJ, Seidler FJ, Qiao D, Slotkin TA: Chlorpyrifos targets developing glia: effects on glial fibrillary acidic protein. Brain Res Dev Brain Res. 2002 Feb 28;133(2):151-61. |
85(1,1,1,5) | Details |
| 16790487 | Mense SM, Sengupta A, Lan C, Zhou M, Bentsman G, Volsky DJ, Whyatt RM, Perera FP, Zhang L: The common insecticides cyfluthrin and chlorpyrifos alter the expression of a subset of genes with diverse functions in primary human astrocytes. Toxicol Sci. 2006 Sep;93(1):125-35. Epub 2006 Jun 21. Further computational and biochemical analyses show that cyfluthrin and chlorpyrifos upregulate certain targets of the interferon-gamma and insulin-signaling pathways and that they increase the protein levels of activated extracellular signal-regulated kinase 1/2, a key component of insulin signaling; interleukin 6, a key inflammatory mediator; and glial fibrillary acidic protein, a marker of inflammatory astrocyte activation. |
31(0,1,1,1) | Details |
| 14555401 | Abdel-Rahman A, Dechkovskaia A, Mehta-Simmons H, Guan X, Khan W, Abou-Donia M: Increased expression of glial fibrillary acidic protein in cerebellum and hippocampus: differential effects on neonatal brain regional acetylcholinesterase following maternal exposure to combined chlorpyrifos and J Toxicol Environ Health A. 2003 Nov 14;66(21):2047-66. |
18(0,0,3,3) | Details |
| 15045467 | Abdel-Rahman A, Dechkovskaia AM, Mehta-Simmons H, Sutton JM, Guan X, Khan WA, Abou-Donia MB: Maternal exposure to and chlorpyrifos, alone and in combination, leads to persistently elevated expression of glial fibrillary acidic protein in the cerebellum of the offspring in late puberty. Arch Toxicol. 2004 Aug;78(8):467-76. Epub 2004 Mar 26. |
14(0,0,2,4) | Details |
| 14718179 | Ehrich M, Hancock S, Ward D, Holladay S, Pung T, Flory L, Hinckley J, Jortner BS: Neurologic and immunologic effects of exposure to chlorpyrifos, and multiple doses of tri-ortho-tolyl over a 28-day period in rats. J Toxicol Environ Health A. 2004 Mar 12;67(5):431-57. However, GFAP was elevated above control levels in the cerebral cortex of rats by all treatments chlorpyrifos, TOTP). |
7(0,0,1,2) | Details |
| 16482470 | Abou-Donia MB, Khan WA, Dechkovskaia AM, Goldstein LB, Bullman SL, Abdel-Rahman A: In utero exposure to and chlorpyrifos alone, and in combination produces persistent sensorimotor deficits and Purkinje neuron loss in the cerebellum of adult offspring rats. Arch Toxicol. 2006 Sep;80(9):620-31. Epub 2006 Feb 16. These results indicate that in utero exposure to and chlorpyrifos, alone and in combination produced significant sensorimotor deficits in male and female offspring, differential increase in brain AChE activity, a decrease in the surviving neurons and an increased expression of GFAP in cerebellum in adult offspring rats at a corresponding human adult age. |
7(0,0,1,2) | Details |
| 19318502 | Dodd CA, Klein BG: Pyrethroid and organophosphate insecticide exposure in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease: an immunohistochemical analysis of tyrosine hydroxylase and glial fibrillary acidic protein in dorsolateral striatum. Toxicol Ind Health. 2009 Feb;25(1):25-39. The pyrethroid insecticide permethrin and the organophosphate insecticide chlorpyrifos can experimentally produce Parkinson's disease (PD)-associated changes in the dopaminergic nigrostriatal pathway, short of frank degeneration, although at doses considerably higher than from a likely environmental exposure. |
3(0,0,0,3) | Details |
| 16675515 | Betancourt AM, Burgess SC, Carr RL: Effect of developmental exposure to chlorpyrifos on the expression of neurotrophin growth factors and cell-specific markers in neonatal rat brain. Toxicol Sci. 2006 Aug;92(2):500-6. Epub 2006 May 4. In addition, the expression of mRNA for the muscarinic acetylcholine receptor (mAChR) M (1) subtype and cell-specific markers for developing neurons (beta-III tubulin), astrocytes (glial fibrillary acidic protein, GFAP), and oligodendrocytes (myelin-associated glycoprotein, MAG) was also investigated. |
2(0,0,0,2) | Details |