| Name | brains |
|---|---|
| Synonyms | BPG dependent PGAM 1; Brain; CDABP0006; PGAM 1; PGAM B; PGAM1; PGAM1 protein; PGAMA… |
| Name | chlorpyrifos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20350560 | Moreira EG, Yu X, Robinson JF, Griffith W, Hong SW, Beyer RP, Bammler TK, Faustman EM: Toxicogenomic profiling in maternal and fetal rodent brains following gestational exposure to chlorpyrifos. Toxicol Appl Pharmacol. 2010 Mar 26. |
6(0,0,1,1) | Details |
| 20142434 | Jiang W, Duysen EG, Hansen H, Shlyakhtenko L, Schopfer LM, Lockridge O: Mice treated with chlorpyrifos or chlorpyrifos oxon have organophosphorylated tubulin in the brain and disrupted microtubule structures, suggesting a role for tubulin in neurotoxicity associated with exposure to organophosphorus agents. Toxicol Sci. 2010 Feb 8. Beta tubulin from the brains of these mice was diethoxyphosphorylated on 281 in peptide GSQQY (281) RALTVPELTQQMFDSK. |
2(0,0,0,2) | Details |
| 10681099 | Lesser J, Blodgett D, Ehrich M: Comparison of oxime-initiated reactivation of organophosphorous-inhibited acetylcholinesterase in brains of avian embryos. J Toxicol Environ Health A. 2000 Jan 14;59(1):57-66. Doses of chlorpyrifos, parathion, acephate, and trichlorfon that inhibited AChE > 70% were administered to the embryos. |
2(0,0,0,2) | Details |
| 16912982 | Williamson LN, Terry AV Jr, Bartlett MG: Determination of chlorpyrifos and its metabolites in rat brain tissue using coupled-column liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom. 2006;20(18):2689-95. Rat brains were homogenized and treated by protein precipitation using ice-cold acetonitrile. |
1(0,0,0,1) | Details |
| 8722258 | Burn JD, Leighton FA: Further studies of brain cholinesterase: cholinergic receptor ratios in the diagnosis of acute lethal poisoning of birds by anticholinesterase pesticides. J Wildl Dis. 1996 Apr;32(2):216-24. Cholinesterase (ChE) and the muscarinic (mAChR) and nicotinic (nAChR) cholinergic receptors were measured in the brains of 86 birds of 20 different species collected in Saskatchewan, Canada during 1991 and 1992. Acute lethal poisoning by the organophosphate chlorpyrifos did not affect the density of mAChR. |
1(0,0,0,1) | Details |
| 17697042 | Gould GG, Brooks BW, Frazer A: [(3) H] binding to serotonin transporter sites in minnow brains. . Basic Clin Pharmacol Toxicol. 2007 Sep;101(3):203-10. Finally, we exposed zebrafish (Danio rerio) to the reuptake inhibiting antidepressant or the organophosphate chlorpyrifos for 21 days. |
1(0,0,0,1) | Details |
| 7522308 | Stanton ME, Mundy WR, Ward T, Dulchinos V, Barry CC: Time-dependent effects of acute chlorpyrifos administration on spatial delayed alternation and cholinergic neurochemistry in weanling rats. Neurotoxicology. 1994 Spring;15(1):201-8. Acetylcholinesterase (AChE) activity and muscaranic receptor density [i.e., quinuclidinyl benzilate (QNB) binding] were determined in hippocampus and cortex of brains taken from pups 15 hours after the end of behavioral testing (i.e., the morning of PND24, and 27). |
1(0,0,0,1) | Details |
| 15840715 | Nomura DK, Leung D, Chiang KP, Quistad GB, Cravatt BF, Casida JE: A brain detoxifying enzyme for organophosphorus nerve poisons. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6195-200. Epub 2005 Apr 19. There are many secondary targets for OP toxicants as observed for example with the major insecticide chlorpyrifos and its bioactivated metabolite chlorpyrifos oxon (CPO). Brains from KIAA1363 (-/-) mice show greatly reduced levels of CPO labeling and hydrolytic metabolism compared to brains from wild-type mice. |
1(0,0,0,1) | Details |
| 18164358 | Nomura DK, Fujioka K, Issa RS, Ward AM, Cravatt BF, Casida JE: Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification. Toxicol Appl Pharmacol. 2008 Apr 1;228(1):42-8. Epub 2007 Dec 3. KIAA1363 was the primary AcMAGE hydrolase in brain, lung, heart and kidney and was highly sensitive to inactivation by chlorpyrifos oxon (CPO) (IC50 2 nM) [the bioactivated metabolite of the major insecticide chlorpyrifos (CPF)]. |
0(0,0,0,0) | Details |