Protein Information

Name demethylase
Synonyms DMTase; Demethylase; MBD 2; MBD2; Methyl CpG binding domain protein 2; Methyl CpG binding protein MBD2; NY CO 41; Demethylases…

Compound Information

Name chlorpyrifos
CAS

Reference List

PubMed Abstract RScore(About this table)
7722883 Lodovici M, Aiolli S, Monserrat C, Dolara P, Medica A, Di Simplicio P: Effect of a mixture of 15 commonly used pesticides on DNA levels of 8-hydroxy-2-deoxyguanosine and xenobiotic metabolizing enzymes in rat liver. J Environ Pathol Toxicol Oncol. 1994;13(3):163-8.

The level of 8-OH-2-deoxyguanosine in rat liver DNA was measured as an index of oxidative damage after treating rats for 10 days at a dose ranging from 0.75 to 10 mg/kg with a mixture of 15 pesticides (dithiocarbamate, benomyl, thiabendazole, diphenylamine, chlorthalonil, procimidone, methidathion, chlorpyrifos-ethyl, fenarimol, parathion-methyl, chlorpropham, parathion, vinclozolin, chlorfenvinphos, pirimiphos-ethyl) commonly found in foods of central Italy.
The administration of the pesticide mixture dose dependently reduced benzo (a) pyrene hydroxylase, N-demethylase activities, glutathione peroxidase, glutathione reductase, glutathione-S-transferase and thiol transferase activities in the liver.
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7535964 Vodela JK, Dalvi RR: Comparative toxicological studies of chlorpyrifos in rats and chickens. Vet Hum Toxicol. 1995 Feb;37(1):1-3.

Oral administration resulted in decreased cytochrome P-450 and aminopyrine N-demethylase activities and increased cytosolic glutathione S-transferase activity in rats.
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10661713 Valles SM, Koehler PG, Brenner RJ: Comparative insecticide susceptibility and detoxification enzyme activities among pestiferous blattodea. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1999 Nov;124(3):227-32.

Lambda-Cyhalothrin LD50 correlated with methoxyresorufin O-demethylase activity (P = 0.01; r = 0.81), carboxylesterase activity (P = 0.03; r = - 0.75), general esterase activity (P = 0.02; r = - 0.79), and cockroach weight (P = 0.01; r = -0.95).
Topical bioassays using propoxur, chlorpyrifos, and lambda-cyhalothrin were conducted on eight cockroach species.
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11976062 Valles SM, Woodson WD: Insecticide susceptibility and detoxication enzyme activities among Coptotermes formosanus Shiraki workers sampled from different locations in New Orleans. Comp Biochem Physiol C Toxicol Pharmacol. 2002 Apr;131(4):469-76.


The termites were subsequently assayed to determine their susceptibility to cypermethrin, chlordane and chlorpyrifos, and detoxication enzyme activity.
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1719272 Pence BC, Demick DS, Richard BC, Buddingh F: The efficacy and safety of chlorpyrifos (Dursban) for control of Myobia musculi infestation in mice. Lab Anim Sci. 1991 Apr;41(2):139-42.

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