Protein Information

Name lactate dehydrogenase (protein family or complex)
Synonyms LDH; lactate dehydrogenase; lactate dehydrogenases

Compound Information

Name chlorpyrifos
CAS

Reference List

PubMed Abstract RScore(About this table)
16334264 Tilak KS, Veeraiah K, Rao DK: Biochemical changes induced by chlorpyrifos, an organophosphate compound in sublethal concentrations to the freshwater fish Catla catla, Labeo rohita and Cirrhinus mrigala. J Environ Biol. 2005 Jun;26(2 Suppl):341-7.

Biochemical changes in total glycogen, total proteins, lactate dehydrogenase (LDH), alanine amino transferase (ALAT) and aspartate amino transferase (AAT) and nucleic acids, Deoxy and ribose, were estimated in the tissues of fishes exposed to the toxicant chlorpyrifos technical grade.
7(0,0,1,2) Details
15620756 Rendon-von Osten J, Ortiz-Arana A, Guilhermino L, Soares AM: In vivo evaluation of three biomarkers in the mosquitofish (Gambusia yucatana) exposed to pesticides. Chemosphere. 2005 Feb;58(5):627-36.

In this study, the acute toxicity and the in vivo effects of commercial chlorpyrifos, carbofuran and glyphosate formulations on cholinesterase (ChE), glutathione S-transferase (GST) and lactate dehydrogenase (LDH) activities of the mosquitofish (Gambusia yucatana) were investigated.
6(0,0,1,1) Details
8560491 Bagchi D, Bagchi M, Hassoun EA, Stohs SJ: In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides. Toxicology. 1995 Dec 15;104(1-3):129-40.

Reactive oxygen species may be involved in the toxicity of various pesticides and we have, therefore, examined the in vivo effects of structurally dissimilar polyhalogenated cyclic hydrocarbons (PCH), such as endrin and chlordane, chlorinated acetamide herbicides (CAH), such as alachlor, and organophosphate pesticides (OPS), such as chlorpyrifos and fenthion, on the production of hepatic and brain lipid peroxidation and DNA-single strand breaks (SSB), two indices of oxidative stress and oxidative tissue damage.
3(0,0,0,3) Details
16378699 Goel A, Dani V, Dhawan DK: Chlorpyrifos-induced alterations in the activities of carbohydrate metabolizing enzymes in rat liver: the role of zinc. Toxicol Lett. 2006 Jun 1;163(3):235-41. Epub 2005 Dec 27.

The effects of different treatment regimens were studied on various enzymes of carbohydrate metabolism in the rat livers, which included hexokinase, glucose-6-phosphatase, fructose-1,6-diphosphatase, glycogen phosphorylase, succinate dehydrogenase (SDH), lactate dehydrogenase (LDH) and the levels of glycogen.
1(0,0,0,1) Details
17980473 Ncibi S, Ben Othman M, Akacha A, Krifi MN, Zourgui L: Opuntia ficus indica extract protects against chlorpyrifos-induced damage on mice liver. Food Chem Toxicol. 2008 Feb;46(2):797-802. Epub 2007 Sep 14.

Liver damage was evaluated by the measure of its weight and the quantification of some biochemical parameters, such as alanine amino transferase (ALAT), aspartate amino transferase (ASAT), phosphatase alkaline (PAL), lactate dehydrogenase (LDH), cholesterol and albumin in serum by spectrophotometric techniques.
1(0,0,0,1) Details