| Name | neurotrophin |
|---|---|
| Synonyms | Abrineurin; BDNF; Brain derived neurotrophic factor; Brain derived neurotrophic factor precursor; Neurotrophin; Brain derived neurotrophic factors; Brain derived neurotrophic factor precursors; Neurotrophins |
| Name | chlorpyrifos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14600285 | Betancourt AM, Carr RL: The effect of chlorpyrifos and chlorpyrifos-oxon on brain cholinesterase, muscarinic receptor binding, and neurotrophin levels in rats following early postnatal exposure. Toxicol Sci. 2004 Jan;77(1):63-71. Epub 2003 Nov 4. |
162(2,2,2,2) | Details |
| 17548533 | Terry AV Jr, Gearhart DA, Beck WD Jr, Truan JN, Middlemore ML, Williamson LN, Bartlett MG, Prendergast MA, Sickles DW, Buccafusco JJ: Chronic, intermittent exposure to chlorpyrifos in rats: protracted effects on axonal transport, neurotrophin receptors, cholinergic markers, and information processing. J Pharmacol Exp Ther. 2007 Sep;322(3):1117-28. Epub 2007 Jun 4. |
82(1,1,1,2) | Details |
| 17893397 | Betancourt AM, Filipov NM, Carr RL: Alteration of neurotrophins in the hippocampus and cerebral cortex of young rats exposed to chlorpyrifos and methyl parathion. Toxicol Sci. 2007 Dec;100(2):445-55. Epub 2007 Sep 24. Exposure to either chlorpyrifos (CPS) or methyl parathion (MPS) results in the inhibition of acetylcholinesterase and leads to altered neuronal activity which normally regulates critical genes such as the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). |
41(0,1,2,6) | Details |
| 16675515 | Betancourt AM, Burgess SC, Carr RL: Effect of developmental exposure to chlorpyrifos on the expression of neurotrophin growth factors and cell-specific markers in neonatal rat brain. Toxicol Sci. 2006 Aug;92(2):500-6. Epub 2006 May 4. |
6(0,0,1,1) | Details |
| 18502319 | Slotkin TA, Seidler FJ, Fumagalli F: Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro. Brain Res Bull. 2008 Jul 1;76(4):424-38. Epub 2008 Feb 1. We administered chlorpyrifos and diazinon to neonatal rats on postnatal days 1-4 at doses devoid of systemic toxicity or growth impairment, and spanning the threshold for barely-detectable cholinesterase inhibition. Using microarrays, we examined the regional expression of mRNAs encoding the neurotrophins (ntfs), brain-derived neurotrophic factor (bdnf), nerve growth factor (ngf), the wnt and fzd gene families and the corresponding receptors. |
1(0,0,0,1) | Details |