| Name | 5HT transporter |
|---|---|
| Synonyms | Sodium dependent serotonin transporter; OCD1; 5 hydroxytryptamine transporter; 5HT transporter; 5HTT; HTT; OCD 1; SERT… |
| Name | chlorpyrifos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17697042 | Gould GG, Brooks BW, Frazer A: [(3) H] binding to serotonin transporter sites in minnow brains. . Basic Clin Pharmacol Toxicol. 2007 Sep;101(3):203-10. However, magnitudes of affinity are similar, and minnow SERT binding is decreased by chronic or chlorpyrifos administration. |
90(1,1,1,10) | Details |
| 14754568 | Aldridge JE, Seidler FJ, Slotkin TA: Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling. Environ Health Perspect. 2004 Feb;112(2):148-55. |
82(1,1,1,2) | Details |
| 18835401 | Slotkin TA, Seidler FJ: Developmental neurotoxicants target neurodifferentiation into the phenotype: Chlorpyrifos, diazinon, dieldrin and divalent Toxicol Appl Pharmacol. 2008 Dec 1;233(2):211-9. Epub 2008 Sep 16. Chlorpyrifos and diazinon both induced tryptophan hydroxylase, the rate-limiting enzyme for 5HT biosynthesis, but chlorpyrifos had a greater effect, and both agents suppressed expression of 5HT transporter genes, effects that would tend to augment extracellular 5HT. |
81(1,1,1,1) | Details |
| 19921154 | Venerosi A, Ricceri L, Rungi A, Sanghez V, Calamandrei G: Gestational exposure to the organophosphate chlorpyrifos alters social-emotional behaviour and impairs responsiveness to the serotonin transporter inhibitor fluvoxamine in mice. Psychopharmacology. 2010 Jan;208(1):99-107. Epub 2009 Nov 18. |
32(0,1,1,2) | Details |
| 11557094 | Raines KW, Seidler FJ, Slotkin TA: Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos. Brain Res Dev Brain Res. 2001 Sep 23;130(1):65-72. |
6(0,0,1,1) | Details |
| 17035140 | Slotkin TA, Tate CA, Ryde IT, Levin ED, Seidler FJ: Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition. Environ Health Perspect. 2006 Oct;114(10):1542-6. OBJECTIVES: We exposed neonatal rats to daily doses of diazinon or parathion on postnatal days (PND) 1-4 and evaluated 5HT receptors and the 5HT transporter in brainstem and forebrain on PND5, focusing on doses of each agent below the maximum tolerated dose and spanning the threshold for cholinesterase inhibition: 0.5, 1, or 2 mg/kg for diazinon, and 0.02, 0.05, and 0.1 mg/kg for parathion. RESULTS: Diazinon evoked up-regulation of 5HT1A and 5HT2 receptor expression even at doses devoid of effects on cholinesterase activity, a pattern similar to that seen earlier for another organophosphate, chlorpyrifos. |
2(0,0,0,2) | Details |
| 14594624 | Aldridge JE, Seidler FJ, Meyer A, Thillai I, Slotkin TA: Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods. Environ Health Perspect. 2003 Nov;111(14):1736-43. Exposure to CPF on GD9-12 elicited initial suppression, immediately followed by rebound elevation, of 5HT1A and 5HT2 receptors as well as the 5HT transporter, all at doses below the threshold for cholinergic hyperstimulation and the resultant systemic toxicity. |
2(0,0,0,2) | Details |
| 18773955 | Slotkin TA, Levin ED, Seidler FJ: Developmental neurotoxicity of parathion: progressive effects on serotonergic systems in adolescence and adulthood. Neurotoxicol Teratol. 2009 Jan-Feb;31(1):11-7. Epub 2008 Aug 20. In adolescence (PN30), young adulthood (PN60) and full adulthood (PN100), we measured radioligand binding to 5HT (1A) and 5HT (2) receptors, and to the 5HT transporter in the brain regions comprising all the major 5HT projections and 5HT cell bodies. These findings stand in strong contrast to previous results with neonatal exposure to a different organophosphate, chlorpyrifos, which evoked parallel upregulation of all three 5HT synaptic proteins that persisted from adolescence through full adulthood and that targeted males much more than females. |
2(0,0,0,2) | Details |
| 18355640 | Slotkin TA, Ryde IT, Levin ED, Seidler FJ: Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: effects on systems in adolescence and adulthood. Brain Res Bull. 2008 Mar 28;75(5):640-7. Epub 2007 Nov 12. We then evaluated the effects on 5HT (1A) and 5HT (2) receptors, and on the 5HT transporter in cerebral cortical regions and the brainstem in adolescence through adulthood. This pattern differed substantially from that seen in earlier work with another organophosphate, chlorpyrifos, which at pharmacodynamically similar doses spanning the threshold for cholinesterase inhibition, evoked a much more substantial, global upregulation of 5HT receptor expression; with chlorpyrifos, effects on receptors were seen in females, albeit to a lesser extent than in males, and were also regionally distinct. |
1(0,0,0,1) | Details |
| 16024092 | Slotkin TA, Seidler FJ: The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent. Brain Res Dev Brain Res. 2005 Aug 8;158(1-2):115-9. To determine if these changes are permanent, we administered 1 mg/kg of CPF daily to neonatal rats on postnatal days 1-4, a regimen devoid of systemic toxicity, and examined 5HT synaptic markers at 5 months of age: radioligand binding to 5HT1A and 5HT2 receptors and to the 5HT transporter. |
1(0,0,0,1) | Details |
| 15710174 | Aldridge JE, Meyer A, Seidler FJ, Slotkin TA: Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions. Toxicol Appl Pharmacol. 2005 Mar 1;203(2):132-44. |
0(0,0,0,0) | Details |