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Quistad GB, Klintenberg R, Casida JE: Blood acylpeptide hydrolase activity is a sensitive marker for exposure to some organophosphate toxicants. Toxicol Sci. 2005 Aug;86(2):291-9. Epub 2005 May 11.
The most potent in vitro inhibitors for human erythrocyte and mouse brain APH are DFP (IC (50) 11-17 nM), chlorpyrifos oxon (IC (50) 21-71 nM), dichlorvos (IC (50) 230-560 nM), naled (IC (50) 370-870 nM), and their analogs with modified alkyl substituents. (3) H-diisopropyl fluorophosphate is a potent inhibitor of mouse blood and brain APH in vivo (ED (50) 0.09-0.2 mg/kg and 0.02-0.03 mg/l for ip and vapor exposure, respectively). |
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