Protein Information

Name metallothionein (protein family or complex)
Synonyms Metallothionein; Metallothioneins

Compound Information

Name chlorpyrifos
CAS

Reference List

PubMed Abstract RScore(About this table)
16378699 Goel A, Dani V, Dhawan DK: Chlorpyrifos-induced alterations in the activities of carbohydrate metabolizing enzymes in rat liver: the role of zinc. Toxicol Lett. 2006 Jun 1;163(3):235-41. Epub 2005 Dec 27.

Levels of metallothionein were also found to be depressed in chlorpyrifos-treated animals, but tended to increase significantly on co-administration of zinc to chlorpyrifos-treated group.
6(0,0,1,1) Details
16169541 Goel A, Dani V, Dhawan DK: Protective effects of zinc on lipid peroxidation, antioxidant enzymes and hepatic histoarchitecture in chlorpyrifos-induced toxicity. Chem Biol Interact. 2005 Oct 20;156(2-3):131-40.

The effects of these treatments were studied on various parameters in rat liver, including lipid peroxidation, antioxidant enzymes, levels of metallothionein (MT) and hepatic histoarchitecture.
1(0,0,0,1) Details
18187192 Roh JY, Choi J: Ecotoxicological evaluation of chlorpyrifos exposure on the nematode Caenorhabditis elegans. Ecotoxicol Environ Saf. 2008 Oct;71(2):483-9. Epub 2008 Jan 9.

The overall results indicate that CP exposure leads to the alteration of the expression of some stress genes, such as of heat shock protein, metallothionein, vitellogenin and C. elegans p53-like protein genes; the inhibition of AChE activity; and the retardation of development.
1(0,0,0,1) Details