| Name | lipase |
|---|---|
| Synonyms | HGL; HPL; HGL; Human giant larvae homolog; LGL 2; LGL2; LLGL 2; LLGL2… |
| Name | chlorpyrifos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11781077 | Bomser JA, Quistad GB, Casida JE: Chlorpyrifos oxon potentiates diacylglycerol-induced extracellular signal-regulated kinase (ERK 44/42) activation, possibly by diacylglycerol lipase inhibition. Toxicol Appl Pharmacol. 2002 Jan 1;178(1):29-36. |
84(1,1,1,4) | Details |
| 16310817 | Quistad GB, Klintenberg R, Caboni P, Liang SN, Casida JE: Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice. Toxicol Appl Pharmacol. 2006 Feb 15;211(1):78-83. Epub 2005 Nov 28. Remarkably high potency and low selectivity is observed with three O-alkyl (C1, C2, C3) alkylphosphonofluoridates (C8, C12) (IC50 0.60-3.0 nM), five S-alkyl (C5, C7, C9) and alkyl (C10, C12) benzodioxaphosphorin oxides (IC50 0.15-5.7 nM) and one OP insecticide metabolite (chlorpyrifos oxon, IC50 34-40 nM). |
6(0,0,0,6) | Details |
| 16449251 | Quistad GB, Liang SN, Fisher KJ, Nomura DK, Casida JE: Each lipase has a unique sensitivity profile for organophosphorus inhibitors. Toxicol Sci. 2006 May;91(1):166-72. Epub 2006 Jan 31. Postheparin lipolytic activity in rat serum is inhibited by 14 OPs, including chlorpyrifos oxon (IC50 50-97 nM). |
5(0,0,0,5) | Details |
| 16978018 | Nomura DK, Durkin KA, Chiang KP, Quistad GB, Cravatt BF, Casida JE: Serine hydrolase KIAA1363: toxicological and structural features with emphasis on organophosphate interactions. Chem Res Toxicol. 2006 Sep;19(9):1142-50. Serine hydrolase KIAA1363 is highly expressed in invasive cancer cells and is the major protein in mouse brain diethylphosphorylated by and hydrolyzing low levels of chlorpyrifos oxon (CPO) (the activated metabolite of a major insecticide). Studies with knockout mice further show that KIAA1363 partially protects brain AChE and monoacylglycerol lipase from CPO-induced in vivo inhibition. |
1(0,0,0,1) | Details |
| 18495101 | Casida JE, Nomura DK, Vose SC, Fujioka K: Organophosphate-sensitive lipases modulate brain lysophospholipids, ether lipids and endocannabinoids. Chem Biol Interact. 2008 Sep 25;175(1-3):355-64. Epub 2008 May 20. It is also a detoxifying enzyme that hydrolyzes chlorpyrifos oxon (CPO) and some other potent insecticide metabolites. Monoacylglycerol lipase and fatty acid amide hydrolase regulate endocannabinoid levels with roles in motility, pain and memory. |
1(0,0,0,1) | Details |
| 17442360 | Crow JA, Borazjani A, Potter PM, Ross MK: Hydrolysis of pyrethroids by human and rat tissues: examination of intestinal, liver and serum carboxylesterases. Toxicol Appl Pharmacol. 2007 May 15;221(1):1-12. Epub 2007 Mar 12. Lastly, two model lipase enzymes were examined for their ability to hydrolyze pyrethroids. |
1(0,0,0,1) | Details |
| 18980129 | Walz I, Schwack W: Reflectometric cutinase assay for rapid screening of contaminants and residues of insecticidal organophosphates and carbamates. J AOAC Int. 2008 Sep-Oct;91(5):1130-7. To meet this need, a completely new application of the reflectometric lipase test (Reflectoquant, Merck) was developed. With this technique, we investigated the inhibition effects of representative insecticides, i.e., chlorpyrifos oxon, paraoxon, and carbaryl. |
1(0,0,0,1) | Details |