Protein Information

Name sex hormone binding globulin
Synonyms ABP; SBP; Androgen binding protein; SHBG; Sex hormone binding globulin; Sex hormone binding globulin precursor; Sex steroid binding protein; TeBG…

Compound Information

Name chlorpyrifos
CAS

Reference List

PubMed Abstract RScore(About this table)
16357596 Meeker JD, Ryan L, Barr DB, Hauser R: Exposure to nonpersistent insecticides and male reproductive hormones. Epidemiology. 2006 Jan;17(1):61-8.

The present study explored the association of urinary concentrations of 3,5,6-trichloro-2-pyridinol (TCPY), a metabolite of chlorpyrifos and chlorpyrifos-methyl, and 1-naphthol (1N), a metabolite of carbaryl and naphthalene, with serum reproductive hormone levels in adult men.
Reproductive hormones (follicle-stimulating hormone, leuteinizing hormone, inhibin B, testosterone, and sex hormone-binding globulin) were measured in serum collected from subjects during the same clinic visit.
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18249523 Meeker JD, Ravi SR, Barr DB, Hauser R: Circulating estradiol in men is inversely related to urinary metabolites of nonpersistent insecticides. Reprod Toxicol. 2008 Feb;25(2):184-91. Epub 2007 Dec 28.

Chlorpyrifos and carbaryl, nonpersistent insecticides to which the general population are commonly exposed, were recently shown to inhibit estradiol metabolism in vitro which could lead to altered hormone balance.
Estradiol, sex hormone binding globulin (SHBG), and prolactin were measured in serum collected from subjects during the same clinic visit.
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