| Name | Nerve growth factor |
|---|---|
| Synonyms | Beta NGF; Beta nerve growth factor; Beta nerve growth factor precursor; HSAN 5; HSAN5; NGF; NGFB; Nerve growth factor… |
| Name | chlorpyrifos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14600285 | Betancourt AM, Carr RL: The effect of chlorpyrifos and chlorpyrifos-oxon on brain cholinesterase, muscarinic receptor binding, and neurotrophin levels in rats following early postnatal exposure. Toxicol Sci. 2004 Jan;77(1):63-71. Epub 2003 Nov 4. The effects of repeated postnatal exposure to CPS and its metabolite chlorpyrifos-oxon (CPO) on total muscarinic acetylcholine receptor (mAChR) binding, nerve growth factor (NGF) levels, and brain derived neurotrophic factor (BDNF) levels in the forebrain of neonatal rats were investigated. |
81(1,1,1,1) | Details |
| 16237519 | Berman-Shlomovich T, Wormser U, Brodsky B: Toxic serum factor long after single exposure to organophosphate; a new approach for biomonitoring. Arch Toxicol. 2006 May;80(5):269-74. Epub 2005 Oct 20. Samples taken 4 weeks after chlorpyrifos exposure reduced nerve growth factor (NGF)-induced neurite outgrowth by 40%. |
81(1,1,1,1) | Details |
| 17893397 | Betancourt AM, Filipov NM, Carr RL: Alteration of neurotrophins in the hippocampus and cerebral cortex of young rats exposed to chlorpyrifos and methyl parathion. Toxicol Sci. 2007 Dec;100(2):445-55. Epub 2007 Sep 24. Exposure to either chlorpyrifos (CPS) or methyl parathion (MPS) results in the inhibition of acetylcholinesterase and leads to altered neuronal activity which normally regulates critical genes such as the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). |
31(0,1,1,1) | Details |
| 10876031 | Crumpton TL, Seidler FJ, Slotkin TA: Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos?. Brain Res Dev Brain Res. 2000 Jun 30;121(2):189-95. Finally, differentiation was initiated with nerve growth factor and the cells were exposed continuously to CPF or CPF oxon over a 72 h period; under these conditions, CPF inhibits neurite outgrowth. |
1(0,0,0,1) | Details |
| 19539729 | Slotkin TA, Seidler FJ: Benzo [a] pyrene impairs neurodifferentiation in PC12 cells. Brain Res Bull. 2009 Aug 28;80(1-2):17-21. Epub 2009 Jun 17. In order to determine if BaP directly affects neurodevelopment, we compared its effects to those of the organophosphate insecticide, chlorpyrifos (CPF), in undifferentiated and differentiating neuronotypic PC12 cells, evaluating indices of cell replication, cell number, neurite outgrowth and phenotypic differentiation. In cells undergoing nerve growth factor-induced differentiation, CPF reduced cell numbers (assessed by DNA content) whereas BaP increased them, suggesting a delay in the transition between cell replication and differentiation. |
1(0,0,0,1) | Details |
| 16675515 | Betancourt AM, Burgess SC, Carr RL: Effect of developmental exposure to chlorpyrifos on the expression of neurotrophin growth factors and cell-specific markers in neonatal rat brain. Toxicol Sci. 2006 Aug;92(2):500-6. Epub 2006 May 4. The effects of postnatal exposure to CPS on the expression of mRNA for two factors critical to brain development, nerve growth factor (NGF) and reelin, were investigated in the forebrain of rats. |
1(0,0,0,1) | Details |
| 18502319 | Slotkin TA, Seidler FJ, Fumagalli F: Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro. Brain Res Bull. 2008 Jul 1;76(4):424-38. Epub 2008 Feb 1. We administered chlorpyrifos and diazinon to neonatal rats on postnatal days 1-4 at doses devoid of systemic toxicity or growth impairment, and spanning the threshold for barely-detectable cholinesterase inhibition. Using microarrays, we examined the regional expression of mRNAs encoding the neurotrophins (ntfs), brain-derived neurotrophic factor (bdnf), nerve growth factor (ngf), the wnt and fzd gene families and the corresponding receptors. |
1(0,0,0,1) | Details |
| 14741763 | Qiao D, Seidler FJ, Violin JD, Slotkin TA: is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos. Brain Res Dev Brain Res. 2003 Dec 30;147(1-2):183-90. Initiation of differentiation with nerve growth factor, which greatly increases the receptor concentration, produced a commensurate increase in the sensitivity of DNA synthesis to while RNA and protein synthesis again remained unaffected. |
1(0,0,0,1) | Details |
| 19801823 | Tan DH, Peng SQ, Wu YL, Wang YM, Lu CF, Ding W, Wang QX, Yan CH: Chlorpyrifos induces delayed cytotoxicity after withdrawal in primary hippocampal neurons through extracellular signal-regulated kinase inhibition. Biol Pharm Bull. 2009 Oct;32(10):1649-55. Carbacol and nerve growth factor (NGF), which are ERK1/2 activators, protected the neurons after CPF withdrawal, while atropine and PD98059, which are ERK1/2 inhibitors, exacerbated the cytotoxicity, indicating the involvement of inhibition of ERK1/2 phosphorylation in CPF-induced delayed cytotoxicity. |
1(0,0,0,1) | Details |
| 9705902 | Song X, Violin JD, Seidler FJ, Slotkin TA: Modeling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cells. Toxicol Appl Pharmacol. 1998 Jul;151(1):182-91. In the current study, we modeled these effects in vitro using rat pheochromocytoma (PC12), a cell line that, upon nerve-growth factor (NGF)-induced differentiation, develops the appearance and function of cholinergic target neurons, including the expression of cholinergic receptors. |
1(0,0,0,1) | Details |
| 16675418 | Jameson RR, Seidler FJ, Qiao D, Slotkin TA: Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells. Environ Health Perspect. 2006 May;114(5):667-72. Upon exposure to nerve growth factor (NGF), PC12 cells developed neuritic projections in association with vastly increased TH and ChAT expression accompanying differentiation into the two phenotypes. |
1(0,0,0,1) | Details |
| 17805420 | Slotkin TA, MacKillop EA, Ryde IT, Seidler FJ: Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells. Environ Health Perspect. 2007 Sep;115(9):1306-13. |
0(0,0,0,0) | Details |
| 15963341 | Qiao D, Seidler FJ, Slotkin TA: Oxidative mechanisms contributing to the developmental neurotoxicity of and chlorpyrifos. Toxicol Appl Pharmacol. 2005 Aug 1;206(1):17-26. Epub 2004 Dec 24. |
0(0,0,0,0) | Details |