| Name | ERK1 |
|---|---|
| Synonyms | ERK 1; ERK1; ERT 2; ERT2; Extracellular signal regulated kinase 1; Extracellular signal related kinase 1b; Extracellular signal related kinase 1c; HS44KDAP… |
| Name | chlorpyrifos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14691213 | Caughlan A, Newhouse K, Namgung U, Xia Z: Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/JNK MAP kinases. Toxicol Sci. 2004 Mar;78(1):125-34. Epub 2003 Dec 22. Furthermore, chlorpyrifos activates the ERK1/2 and p38 MAP kinases. |
144(1,3,3,4) | Details |
| 16790487 | Mense SM, Sengupta A, Lan C, Zhou M, Bentsman G, Volsky DJ, Whyatt RM, Perera FP, Zhang L: The common insecticides cyfluthrin and chlorpyrifos alter the expression of a subset of genes with diverse functions in primary human astrocytes. Toxicol Sci. 2006 Sep;93(1):125-35. Epub 2006 Jun 21. Further computational and biochemical analyses show that cyfluthrin and chlorpyrifos upregulate certain targets of the interferon-gamma and insulin-signaling pathways and that they increase the protein levels of activated extracellular signal-regulated kinase 1/2, a key component of insulin signaling; interleukin 6, a key inflammatory mediator; and glial fibrillary acidic protein, a marker of inflammatory astrocyte activation. |
31(0,1,1,1) | Details |
| 19801823 | Tan DH, Peng SQ, Wu YL, Wang YM, Lu CF, Ding W, Wang QX, Yan CH: Chlorpyrifos induces delayed cytotoxicity after withdrawal in primary hippocampal neurons through extracellular signal-regulated kinase inhibition. Biol Pharm Bull. 2009 Oct;32(10):1649-55. However, CPF withdrawal after 48 h exposure led to inhibition of ERK1/2 phosphorylation. |
3(0,0,0,3) | Details |