Protein Information

Name dopamine transporter
Synonyms DA transporter; DAT1; DAT; DAT 1; Dopamine transporter; SLC6A3; Sodium dependent dopamine transporter; Dopamine transporters…

Compound Information

Name chlorpyrifos
CAS

Reference List

PubMed Abstract RScore(About this table)
16081522 Padilla S, Marshall RS, Hunter DL, Oxendine S, Moser VC, Southerland SB, Mailman RB: Neurochemical effects of chronic dietary and repeated high-level acute exposure to chlorpyrifos in rats. Toxicol Sci. 2005 Nov;88(1):161-71. Epub 2005 Aug 4.

Muscarinic receptor density was assessed in retina, pons, and brain, whereas dopamine transporter density and the levels of dopamine and its metabolites were assessed in striatum.
2(0,0,0,2) Details
12428726 Bloomquist JR, Barlow RL, Gillette JS, Li W, Kirby ML: Selective effects of insecticides on nigrostriatal dopaminergic nerve pathways. Neurotoxicology. 2002 Oct;23(4-5):537-44.

For in vivo exposures, C57BL/6 mice were treated three times over a 2-week period with heptachlor, the pyrethroids deltamethrin and permethrin, or chlorpyrifos.
Western blot analysis confirmed increased levels of dopamine transporter (DAT) protein in the striatum of mice treated with heptachlor and permethrin.
1(0,0,0,1) Details