| Name | albumin |
|---|---|
| Synonyms | ALB; Albumin; PRO0883; PRO0903; PRO1341; PRO1708; PRO2044; PRO2619… |
| Name | closantel |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9138034 | Rothwell J, Sangster N: Haemonchus contortus: the uptake and metabolism of closantel. . Int J Parasitol. 1997 Mar;27(3):313-9. This reduced accumulation of drug could contribute to closantel resistance by mechanisms such as reduced feeding, failure to dissociate the drug-albumin complex in the gut or increased efflux of closantel from resistant worms. |
87(1,1,2,2) | Details |
| 7571353 | McEntee K, Grauwels M, Clercx C, Henroteaux M: Closantel intoxication in a dog. Vet Hum Toxicol. 1995 Jun;37(3):234-6. The therapy included albumin administration to reduce the acute toxicity of closantel. |
81(1,1,1,1) | Details |
| 3330516 | Michiels M, Meuldermans W, Heykants J: The metabolism and fate of closantel (Flukiver) in sheep and cattle. Drug Metab Rev. 1987;18(2-3):235-51. Closantel bound strongly (greater than 99.9%) and almost exclusively to plasma albumin. |
81(1,1,1,1) | Details |
| 10856512 | Rothwell JT, Lacey E, Sangster NC: The binding of closantel to ovine serum albumin, and homogenate fractions of Haemonchus contortus. Int J Parasitol. 2000 May;30(6):769-75. Closantel binds specifically to ovine serum albumin (K (a) of 9. 3x10 (6) M (-1)) at site I, the /phenylbutazone binding site of albumin Closantel also binds to invertebrate haemocyanin and haemolymph. |
81(1,1,1,1) | Details |
| 4011323 | Vanden Bossche H: How anthelmintics help us to understand helminths. Parasitology. 1985 Apr;90 ( Pt 4):675-85. Study of the mode of action of the anti-parasitic 'hydrogenophore', closantel, revealed that mitochondria isolated from livers of untreated rats, 13 weeks after infection with Fasciola hepatica metacercariae, were uncoupled. The lipid extractable product (s) binds to albumin and has a molecular weight between 500 and 1000 Daltons. |
1(0,0,0,1) | Details |