| Name | acetylcholine receptors (protein family or complex) |
|---|---|
| Synonyms | Acetylcholine receptor; Acetylcholine receptors |
| Name | closantel |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9309773 | Martin RJ, Robertson AP, Bjorn H: Target sites of anthelmintics. Parasitology. 1997;114 Suppl:S111-24. This paper reviews sites of action of anthelmintic drugs including: (1) levamisole and pyrantel, which act as agonists at nicotinic acetylcholine receptors of nematodes; (2) the avermectins, which potentiate or gate the opening of glutamategated channels found only in invertebrates; (3) piperazine, which acts as an agonist at gated channels on nematode muscle; (4) praziquantel, which increases the permeability of trematode tegument to and results in contraction of the parasite muscle; (5) the benzimidazoles, like thiabendazole, which bind selectively to parasite beta-tubulin and prevents microtubule formation; (6) the ionophores, like closantel, which uncouple oxidative phosphorylation; (7) diamphenethide and clorsulon, which selectively inhibit metabolism of Fasciola and; (8) diethylcarbamazine, which appears to interfere with arachidonic acid metabolism of filarial parasites and host. |
31(0,1,1,1) | Details |
| 9265850 | Martin RJ: Modes of action of anthelmintic drugs. Vet J. 1997 Jul;154(1):11-34. The salicylanilides: rafoxanide, oxyclozanide, brotianide and closantel and the substituted nitroxynil, are ionophores. Levamisole, pyrantel and morantel are agonists at nicotinic acetylcholine receptors of nematode muscle and cause spastic paralysis. |
1(0,0,0,1) | Details |