Protein Information

Name P glycoprotein
Synonyms ABC20; MDR1; ABCB 1; ABCB1; ATP binding cassette sub family B member 1; CD243; CD243 antigen; CLCS…

Compound Information

Name cypermethrin
CAS cyano(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate

Reference List

PubMed Abstract RScore(About this table)
17490606 Sreeramulu K, Liu R, Sharom FJ: Interaction of insecticides with mammalian P-glycoprotein and their effect on its transport function. Biochim Biophys Acta. 2007 Jul;1768(7):1750-7. Epub 2007 Apr 5.

We studied the effects of four commonly used insecticides (methylparathion, endosulfan, cypermethrin and fenvalerate) on P-glycoprotein isolated from multidrug-resistant cells.
10(0,0,1,5) Details
12109718 Buss DS, McCaffery AR, Callaghan A: Evidence for p-glycoprotein modification of insecticide toxicity in mosquitoes of the Culex pipiens complex. Med Vet Entomol. 2002 Jun;16(2):218-22.

Verapamil increased toxicity to examples of three insecticide classes (cypermethrin, endosulfan, ivermectin), but not to chlorpyrifos (organophosphate).
7(0,0,0,7) Details
17215890 Aurade R, Jayalakshmi SK, Sreeramulu K: Stimulatory effect of insecticides on partially purified P-glycoprotein ATPase from the resistant pest Helicoverpa armigera. Biochem Cell Biol. 2006 Dec;84(6):1045-50.

The partially purified Ha-Pgp ATPase was reconstituted into proteoliposomes and it was found that some insecticides, namely, monocrotophos, endosulfan, cypermethrin, fenvalerate, and methylparathion, stimulated the ATPase activity.
2(0,0,0,2) Details
15171950 Srinivas R, Udikeri SS, Jayalakshmi SK, Sreeramulu K: Identification of factors responsible for insecticide resistance in Helicoverpa armigera. Comp Biochem Physiol C Toxicol Pharmacol. 2004 Mar;137(3):261-9.

Our results indicate that the high level of resistance detected in the field pests could be because of a combined effect of decreased sensitivity to AChE, higher levels of esterases, phosphatases and the expression of P-gp.
Moth larvae (Helicoverpa armigera Hubner) collected from field crops were tested for resistance to cypermethrin, fenvalerate, endosulfan, monocrotophos and quinolphos.
1(0,0,0,1) Details