Protein Information

Name cystathionine gamma lyase
Synonyms CTH; Cystathionase; Cystathionase isoform 1 variant; Cystathionine gamma lyase; Cysteine desulfhydrase; Gamma cystathionase; Homoserine deaminase; Homoserine dehydratase…

Compound Information

Name sulfur
CAS sulfur

Reference List

PubMed Abstract RScore(About this table)
19886835 Toohey JI: Sulfur metabolism in AIDS: cystamine as an anti-HIV agent. AIDS Res Hum Retroviruses. 2009 Nov;25(11):1057-60.

Cystamine has been shown to cause marked suppression of HIV replication in cultured lymphocytes and macrophages; the inference is that the cystamine/diamine oxidase system may replace the cystine/cystathionase system as a source of sulfane sulfur.
34(0,1,1,4) Details
19776584 Lee JS, Kwon KA, Jung HS, Kim JH, Hahm KB: Korea red ginseng on Helicobacter pylori-induced halitosis: newer therapeutic strategy and a plausible mechanism. Digestion. 2009;80(3):192-9. Epub 2009 Sep 16.

BACKGROUND: Gas chromatographic documentation of volatile sulfur compounds in Helicobacter pylori cultures and the amelioration of halitosis after eradication suggested a causal link between H. pylori infection and halitosis.
The expressions of cystathionine gamma-lyase (CSE), cystathionine beta-synthetase (CBS), IL-6, IL-8 and IL-1beta mRNA were compared in H. pylori-infected or NaHS-treated gastric epithelial cells according to red ginseng treatment.
1(0,0,0,1) Details
19889863 Olson KR, Whitfield NL, Bearden SE, St Leger J, Nilson E, Gao Y, Madden JA: Hypoxic pulmonary vasodilation: a paradigm shift with a hydrogen sulfide mechanism. Am J Physiol Regul Integr Comp Physiol. 2010 Jan;298(1):R51-60. Epub 2009 Nov 4.

H (2) S-synthesizing enzymes, cystathionine beta-synthase, cystathionine gamma-lyase, and 3-mercaptopyruvate sulfur transferase, were identified in lung tissue from both animals by one-dimensional Western blot analysis and immunohistochemistry.
6(0,0,1,1) Details
19531479 Singh S, Padovani D, Leslie RA, Chiku T, Banerjee R: Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative trans-sulfuration reactions. J Biol Chem. 2009 Aug 14;284(33):22457-66. Epub 2009 Jun 16.

Finally, our studies reveal that the profligacy of the trans-sulfuration pathway results not only in a multiplicity of H2S-yielding reactions but also yields novel thioether metabolites, thus increasing the complexity of the sulfur metabolome.
2(0,0,0,2) Details
20162368 Stipanuk MH, Ueki I: Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur. J Inherit Metab Dis. 2010 Feb 17.

Cysteine desulfuration is accomplished by alternate reactions catalyzed by cystathionine beta-synthase and cystathionine gamma-lyase.
1(0,0,0,1) Details
20191298 Kimura H: Hydrogen sulfide: its production, release and functions. . Amino Acids. 2010 Feb 27.

It is produced by three enzymes, cystathionine beta-synthase, cystathionine gamma-lyase and 3-mercaptopyruvate sulfurtransferase along with cysteine aminotransferase.
In addition to an immediate release of H (2) S from producing enzymes, it can be stored as bound sulfane sulfur, which may release H (2) S in response to physiological stimuli.
1(0,0,0,1) Details
20357079 Sikalidis AK, Stipanuk MH: Growing Rats Respond to a Sulfur Amino Acid-Deficient Diet by Phosphorylation of {alpha} Subunit of Eukaryotic Initiation Factor 2 Heterotrimeric Complex and Induction of Adaptive Components of the Integrated Stress Response. J Nutr. 2010 Mar 31.

Analysis of liver from rats fed these diets for 7 d showed that the SAA-deficient rats had higher levels of eIF2alpha phosphorylation and higher levels of activating transcription factor (ATF) 4, ATF3, asparagine synthetase, solute carrier 7A11, cysteinyl-tRNA synthetase, and cystathionine gamma-lyase.
1(0,0,0,1) Details