| Name | caspase 3 |
|---|---|
| Synonyms | Apopain; CASP 3; CASP3; CPP 32; CPP32; CPP32B; Caspase 3; Caspase 3 precursor… |
| Name | DDT |
|---|---|
| CAS | 1,1′-(2,2,2-trichloroethylidene)bis[4-chlorobenzene] |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19644561 | Shi Y, Song Y, Wang Y, Liang X, Hu Y, Guan X, Cheng J, Yang K: p,p'-DDE induces apoptosis of rat Sertoli cells via a FasL-dependent pathway. J Biomed Biotechnol. 2009;2009:181282. Epub 2009 Jul 22. In addition, caspase-3 and -8 were activated by p,p'-DDE treatment in these cells. |
1(0,0,0,1) | Details |
| 17556801 | Wojtowicz AK, Augustowska K, Gregoraszczuk EL: The short- and long-term effects of two isomers of DDT and their metabolite DDE on hormone secretion and survival of human choriocarcinoma JEG-3 cells. Pharmacol Rep. 2007 Mar-Apr;59(2):224-32. Decrease in caspase-3 activity was observed in cells exposed to both isomers of DDT and its metabolites. |
1(0,0,0,1) | Details |
| 15603917 | Frigo DE, Vigh KA, Struckhoff AP, Elliott S, Beckman BS, Burow ME, McLachlan JA: Xenobiotic-induced TNF-alpha expression and apoptosis through the p38 MAPK signaling pathway. Toxicol Lett. 2005 Feb 15;155(2):227-38. Furthermore, DDT-induced p38 activity led to the release of cytochrome c from the mitochondria and activation of caspase-3/7. |
1(0,0,0,1) | Details |
| 20025943 | Shi YQ, Wang YP, Song Y, Li HW, Liu CJ, Wu ZG, Yang KD: p,p'-DDE induces testicular apoptosis in prepubertal rats via the Fas/FasL pathway. Toxicol Lett. 2009 Dec 16. Significant elevations in the mRNA levels of Fas along with an increase in FasL, caspase-3, -8 were observed in 100mg/kg b.wt group. |
2(0,0,0,2) | Details |
| 19545618 | Alegria-Torres JA, Diaz-Barriga F, Gandolfi AJ, Perez-Maldonado IN: Mechanisms of p,p'-DDE-induced apoptosis in human peripheral blood mononuclear cells. Toxicol In Vitro. 2009 Sep;23(6):1000-6. Epub 2009 Jun 21. Moreover, when PBMC were treated with high p,p'-DDE concentration (80 microg/ml) several apoptotic biochemical events were triggered, such as activation of caspase-8, Bid, caspase-9 and caspase-3, as well as degradation of PARP and ubiquitination. |
1(0,0,0,1) | Details |
| 18406082 | Gregoraszczuk EL, Rak A, Kawalec K, Ropstad E: Steroid secretion following exposure of ovarian follicular cells to single congeners and defined mixture of polybrominateddibenzoethers (PBDEs), p,p'-DDT and its metabolite p,p'-DDE. Toxicol Lett. 2008 May 5;178(2):103-9. Epub 2008 Mar 8. Media samples were collected and used for cell viability and steroid determination, while cells were used for the measurement of caspase-3 activity. |
1(0,0,0,1) | Details |
| 18692563 | Gregoraszczuk EL, Ptak A, Karniewska M, Ropstad E: Action of defined mixtures of PCBs, p,p'-DDT and its metabolite p,p'-DDE, on co-culture of porcine theca and granulosa cells: steroid secretion, cell proliferation and apoptosis. Reprod Toxicol. 2008 Oct;26(2):170-4. Epub 2008 Jul 22. At the end of culture media samples were collected and used for cell viability and steroid determination, and cells were used for the measurement of caspase-3 activity. |
1(0,0,0,1) | Details |