| PubMed |
Abstract |
RScore(About this table) |
| 18791200 |
Bratton MR, Frigo DE, Vigh-Conrad KA, Fan D, Wadsworth S, McLachlan JA, Burow ME: Organochlorine-mediated potentiation of the general coactivator p300 through p38 mitogen-activated protein kinase. Carcinogenesis. 2009 Jan;30(1):106-13. Epub 2008 Sep 12.
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3(0,0,0,3) |
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| 18840457 |
Han EH, Kim JY, Kim HK, Hwang YP, Jeong HG: o,p'-DDT induces cyclooxygenase-2 gene expression in murine macrophages: Role of AP-1 and CRE promoter elements and PI3-kinase/Akt/MAPK signaling pathways. Toxicol Appl Pharmacol. 2008 Dec 1;233(2):333-42. Epub 2008 Sep 18.
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2(0,0,0,2) |
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| 15603917 |
Frigo DE, Vigh KA, Struckhoff AP, Elliott S, Beckman BS, Burow ME, McLachlan JA: Xenobiotic-induced TNF-alpha expression and apoptosis through the p38 MAPK signaling pathway. Toxicol Lett. 2005 Feb 15;155(2):227-38.
In search for a molecular mechanism we recently established that DDT and its metabolites stimulate activator protein-1 (AP-1)-mediated gene expression through the p38 mitogen-activated protein kinase (MAPK) cascade. |
2(0,0,0,2) |
Details |
| 14604893 |
Frigo DE, Tang Y, Beckman BS, Scandurro AB, Alam J, Burow ME, McLachlan JA: Mechanism of AP-1-mediated gene expression by select organochlorines through the p38 MAPK pathway. Carcinogenesis. 2004 Feb;25(2):249-61. Epub 2003 Nov 6.
Here, we show that the organochlorine pesticide dichlorodiphenyltrichloroethane (DDT) and its metabolites induce a stress mitogen-activated protein kinase (MAPK) that leads to AP-1 activation. |
1(0,0,0,1) |
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