| Name | activator protein 1 |
|---|---|
| Synonyms | AP1; Activator protein 1; JUN; Proto oncogene c jun; Protooncogene c jun; Transcription factor AP 1; V jun avian sarcoma virus 17 oncogene homolog; c Jun… |
| Name | DDT |
|---|---|
| CAS | 1,1′-(2,2,2-trichloroethylidene)bis[4-chlorobenzene] |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15026083 | Fujimoto N, Kitamura S: Effects of environmental estrogenic chemicals on AP1 mediated transcription with estrogen receptors alpha and beta. J Steroid Biochem Mol Biol. 2004 Jan;88(1):53-9. |
4(0,0,0,4) | Details |
| 19828838 | Jajoo S, Mukherjea D, Kumar S, Sheth S, Kaur T, Rybak LP, Ramkumar V: Role of beta-arrestin1/ERK MAP kinase pathway in regulating adenosine A1 receptor desensitization and recovery. Am J Physiol Cell Physiol. 2010 Jan;298(1):C56-65. Epub 2009 Oct 14. Knockdown of beta-arrestin1 by short interfering RNA (siRNA) blocked R-PIA-mediated downregulation of the A (1) AR, suppressed R-PIA-dependent ERK1/2 and activator protein-1 (AP-1) activity, and reduced the induction of A (1) AR mRNA. |
1(0,0,0,1) | Details |
| 14604893 | Frigo DE, Tang Y, Beckman BS, Scandurro AB, Alam J, Burow ME, McLachlan JA: Mechanism of AP-1-mediated gene expression by select organochlorines through the p38 MAPK pathway. Carcinogenesis. 2004 Feb;25(2):249-61. Epub 2003 Nov 6. DDT stimulates an AP-1 complex shift at the DNA to one favoring c-Jun/c-Fos dimers through both increasing c-Jun levels and by post-translational activation of c-Jun and c-Fos in HEK 293 and human endometrial Ishikawa cells. |
1(0,0,0,1) | Details |
| 18791200 | Bratton MR, Frigo DE, Vigh-Conrad KA, Fan D, Wadsworth S, McLachlan JA, Burow ME: Organochlorine-mediated potentiation of the general coactivator p300 through p38 mitogen-activated protein kinase. Carcinogenesis. 2009 Jan;30(1):106-13. Epub 2008 Sep 12. We have previously shown that the organochlorine pesticide dichlorodiphenyltrichloroethane (DDT) stimulates activator protein-1 activity through the p38 mitogen-activated protein kinase (MAPK). |
1(0,0,0,1) | Details |
| 15603917 | Frigo DE, Vigh KA, Struckhoff AP, Elliott S, Beckman BS, Burow ME, McLachlan JA: Xenobiotic-induced TNF-alpha expression and apoptosis through the p38 MAPK signaling pathway. Toxicol Lett. 2005 Feb 15;155(2):227-38. In search for a molecular mechanism we recently established that DDT and its metabolites stimulate activator protein-1 (AP-1)-mediated gene expression through the p38 mitogen-activated protein kinase (MAPK) cascade. |
1(0,0,0,1) | Details |