| Name | pregnane X receptor |
|---|---|
| Synonyms | BXR; PAR; PAR1; NR1I2; ONR 1; ONR1; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR… |
| Name | DDT |
|---|---|
| CAS | 1,1′-(2,2,2-trichloroethylidene)bis[4-chlorobenzene] |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17692354 | Petersen MS, Halling J, Damkier P, Nielsen F, Grandjean P, Weihe P, Brosen K: Polychlorinated biphenyl (PCB) induction of CYP3A4 enzyme activity in healthy Faroese adults. Toxicol Appl Pharmacol. 2007 Oct 15;224(2):202-6. Epub 2007 Jul 14. A commercial polychlorinated biphenyl (PCB) mixture, 1,1,1,-trichloro-2-(o-chlorophenyl), 2-(p'-chlorophenyl) ethane (o,p'-DDT) and 1,1,-dichloro-2,2-bis (p-chlorophenyl) ethene (p,p'-DDE) are known to induce CYP3A4 activity through activation of nuclear receptors, such as the pregnane X receptor. |
1(0,0,0,1) | Details |
| 16764480 | Mortensen AS, Arukwe A: The persistent DDT metabolite, 1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene, alters thyroid hormone-dependent genes, hepatic cytochrome P4503A, and pregnane X receptor gene expressions in Atlantic salmon (Salmo salar) Parr. Environ Toxicol Chem. 2006 Jun;25(6):1607-15. |
2(0,0,0,2) | Details |
| 12869653 | Wyde ME, Bartolucci E, Ueda A, Zhang H, Yan B, Negishi M, You L: The environmental pollutant 1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene induces rat hepatic cytochrome P450 2B and 3A expression through the constitutive androstane receptor and pregnane X receptor. Mol Pharmacol. 2003 Aug;64(2):474-81. |
2(0,0,0,2) | Details |
| 17984292 | Kiyosawa N, Kwekel JC, Burgoon LD, Williams KJ, Tashiro C, Chittim B, Zacharewski TR: o,p'-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver. Toxicol Sci. 2008 Feb;101(2):350-63. Epub 2007 Nov 5. Genes associated with drug metabolism (Cyp2b2 and Cyp3a2), the nuclear receptors constitutive androstane receptor (CAR) and pregnane X receptor (PXR), cell proliferation (Ccnd1, Ccnb1, Ccnb2, and Stmn1), and oxidative stress (Gclm and Hmox1) were significantly induced. |
1(0,0,0,1) | Details |
| 16054614 | Kretschmer XC, Baldwin WS: CAR and PXR: xenosensors of endocrine disrupters? . Chem Biol Interact. 2005 Aug 15;155(3):111-28. The pregnane X-receptor (PXR) and the constitutive androstane receptor (CAR) are orphan nuclear receptors activated by a variety of ligands. |
1(0,0,0,1) | Details |
| 17035600 | Medina-Diaz IM, Arteaga-Illan G, de Leon MB, Cisneros B, Sierra-Santoyo A, Vega L, Gonzalez FJ, Elizondo G: Pregnane X receptor-dependent induction of the CYP3A4 gene by o,p'-1,1,1,-trichloro-2,2-bis (p-chlorophenyl) ethane. Drug Metab Dispos. 2007 Jan;35(1):95-102. Epub 2006 Oct 11. |
1(0,0,0,1) | Details |
| 17526421 | Niimi S, Kim EY, Iwata H, Watanabe MX, Yasunaga G, Fujise Y, Tanabe S: Identification and hepatic expression profiles of cytochrome P450 1-4 isozymes in common minke whales (Balaenoptera acutorostrata). Comp Biochem Physiol B Biochem Mol Biol. 2007 Aug;147(4):667-81. Epub 2007 Apr 14. A strong positive correlation between CYP2C78 and 3A72 (r=0.90, p <0.001) suggests that expression of these CYP isozymes may be under a regulation mechanism of cross-talk in which specific nuclear receptors such as constitutive androstane receptor and pregnane X receptor are involved. |
1(0,0,0,1) | Details |