Protein Information

Name CD4
Synonyms CD4; CD4 antigen (p55); CD4 molecule; CD4mut; T cell antigen T4/LEU3; T cell surface glycoprotein CD4; T cell surface antigen T4/Leu 3; T cell surface glycoprotein CD4 precursor…

Compound Information

Name DDT
CAS 1,1′-(2,2,2-trichloroethylidene)bis[4-chlorobenzene]

Reference List

PubMed Abstract RScore(About this table)
17222440 Nagayama J, Tsuji H, Iida T, Nakagawa R, Matsueda T, Hirakawa H, Yanagawa T, Fukushige J, Watanabe T: Immunologic effects of perinatal exposure to dioxins, PCBs and organochlorine pesticides in Japanese infants. Chemosphere. 2007 Apr;67(9):S393-8. Epub 2007 Jan 11.


Lymphocyte subsets such as CD16+, HLA-DR+, CD4+, CD4+8+, CD8+, CD3+ and CD20+ cells in peripheral venous blood were assessed in a subgroup of 92 infants.
2(0,0,0,2) Details
19762394 Li J, McMurray RW: Effects of chronic exposure to DDT and TCDD on disease activity in murine systemic lupus erythematosus. Lupus. 2009 Oct;18(11):941-9.


Also, TCDD group had significantly lower thymic and splenic weights, decreased percentages of CD4 (+) CD8 (+) thymocytes and splenic CD4 (+) T cells, increased percentage of splenic B220 (+) sIgM (+) B cells and higher serum interferon gamma concentration.
1(0,0,0,1) Details
16696175 Ndebele K, Tchounwou PB, McMurray RW: Coumestrol, bisphenol-A, DDT, and TCDD modulation of interleukin-2 expression in activated CD+4 Jurkat T cells. Int J Environ Res Public Health. 2004 Mar;1(1):3-11.


In this research, we examined the effects and potential mechanisms of action of these estrogenic compounds on IL-2 production in activated CD4+ Jurkat T cells.
1(0,0,0,1) Details