Protein Information

Name CYP1A1
Synonyms AHH; AHRR; Arylhydrocarbon hydroxylase; CP11; CYP 1; CYP1; CYP1A1; CYPIA 1…

Compound Information

Name DDT
CAS 1,1′-(2,2,2-trichloroethylidene)bis[4-chlorobenzene]

Reference List

PubMed Abstract RScore(About this table)
16792888 Li JY, Wu DS, Yang F, Zeng HY, Lei FM, Zhou WD, Li H, Tao P: [Study on serum organochlorines pesticides (DDTs) level, CYP1A1 genetic polymorphism and risk of breast cancer: a case control study]. Zhonghua Liu Xing Bing Xue Za Zhi. 2006 Mar;27(3):217-22.

6(0,0,0,6) Details
17654248 Han EH, Jeong TC, Jeong HG: Methoxychlor suppresses the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible CYP1A1 expression in murine Hepa-1c1c7 cells. J Toxicol Environ Health A. 2007 Aug;70(15-16):1304-9.

5(0,0,0,5) Details
17311112 Ociepa-Zawal M, Rubis B, Lacinski M, Trzeciak WH: The effect of indole-3-carbinol on the expression of CYP1A1, CYP1B1 and AhR genes and proliferation of MCF-7 cells. Acta Biochim Pol. 2007;54(1):113-7. Epub 2007 Feb 20.

3(0,0,0,3) Details
19303595 Messaros BM, Rossano MG, Liu G, Diamond MP, Friderici K, Nummy-Jernigan K, Daly D, Puscheck E, Paneth N, Wirth JJ: Negative effects of serum p,p'-DDE on sperm parameters and modification by genetic polymorphisms. Environ Res. 2009 May;109(4):457-64. Epub 2009 Mar 20.


Serum was analyzed for organochlorines (OC) and DNA for polymorphisms in GSTM1, GSTT1, GSTP1 and CYP1A1.
3(0,0,0,3) Details
17526421 Niimi S, Kim EY, Iwata H, Watanabe MX, Yasunaga G, Fujise Y, Tanabe S: Identification and hepatic expression profiles of cytochrome P450 1-4 isozymes in common minke whales (Balaenoptera acutorostrata). Comp Biochem Physiol B Biochem Mol Biol. 2007 Aug;147(4):667-81. Epub 2007 Apr 14.


Relationships among hepatic mRNA expression levels of these CYP2-4 isozymes together with CYP1A1 and CYP1A2 were also examined.
2(0,0,0,2) Details
18835349 Minh SD, Below S, Muller C, Hildebrandt JP: Novel mammalian cell lines expressing reporter genes for the detection of environmental chemicals activating endogenous aryl hydrocarbon receptors (ArhR) or estrogen receptors (ER). Toxicol In Vitro. 2008 Dec;22(8):1935-47. Epub 2008 Sep 15.


We have constructed two vector systems (pDMS5, pSAB2) containing the promoter regions of the human CYP1A1 gene including xenobiotic response elements or the promoter region of the Xenopus laevis vitellogenin A2 gene including estrogen response elements, respectively, and the genes for green fluorescent protein and firefly luciferase.
1(0,0,0,1) Details