Protein Information

Name follicle stimulating hormone (protein family or complex)
Synonyms Follicle stimulating hormone; Follitropin; Follitropins

Compound Information

Name DDT
CAS 1,1′-(2,2,2-trichloroethylidene)bis[4-chlorobenzene]

Reference List

PubMed Abstract RScore(About this table)
17157474 Bernard L, Martinat N, Lecureuil C, Crepieux P, Reiter E, Tilloy-Ellul A, Chevalier S, Guillou F: Dichlorodiphenyltrichloroethane impairs follicle-stimulating hormone receptor-mediated signaling in rat Sertoli cells. Reprod Toxicol. 2007 Feb;23(2):158-64. Epub 2006 Nov 10.


DDT inhibited the cAMP response to follicle-stimulating hormone (FSH), the major endocrine control of Sertoli cell development, and to a beta2-agonist, isoproterenol.
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15964612 Asawasinsopon R, Prapamontol T, Prakobvitayakit O, Vaneesorn Y, Mangklabruks A, Hock B: Plasma levels of DDT and their association with reproductive hormones in adult men from northern Thailand. Sci Total Environ. 2006 Feb 15;355(1-3):98-105. Epub 2005 Jun 17.


Venous blood samples were collected for measuring plasma levels of DDT and its metabolites and reproductive hormones, including 17beta-estradiol (E2), testosterone, luteinizing hormone (LH), and follicle stimulating hormone (FSH). 1,1-Dichloro-2,2-di (4-chlorophenyl) ethylene (p,p'-DDE) and 1,1,1-trichloro-2,2-di (4-chlorophenyl) ethane (p,p'-DDT) were detected in all plasma samples. p,p'-DDE had the highest level with a median of 4057.7 ng/g lipids and a relatively higher level compared with most other studies.
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16329587 Liu GH, Yang KD, Liu XP, Qin QF: [Effects of residues of organochlorine pesticides on reproductive endocrine in human]. Wei Sheng Yan Jiu. 2005 Sep;34(5):524-8.


RESULTS: (1) With the increase of blood burden of organochlorine pesticides, levels of the hormones such as follicle stimulating hormone (FSH), estradiol (E2) and progesterone (P) in the maternal blood and FSH, luteinizing hormone (LH) and E2 in the umbilical cord blood increased in dose-effect manner, respectively.
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16901337 Dalvie MA, Myers JE: The relationship between reproductive outcome measures in DDT exposed malaria vector control workers: a cross-sectional study. J Occup Med Toxicol. 2006 Aug 10;1:21.


Tests included blood basal and post gonadotrophin releasing hormone (GnRH), luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone, sex hormone binding globulin (SHBG), estradiol (E2) and inhibin; a questionnaire (demographics and general medical history); a physical examination and semen analysis.
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15261779 Dalvie MA, Myers JE, Lou Thompson M, Dyer S, Robins TG, Omar S, Riebow J, Molekwa J, Kruger P, Millar R: The hormonal effects of long-term DDT exposure on malaria vector-control workers in Limpopo Province, South Africa. Environ Res. 2004 Sep;96(1):9-19.


Serum o'p' and p'p' isomers of DDE, DDT, and DDD and basal and post-GnRH challenge hormone levels, including luteinizing hormone, follicle-stimulating hormone, testosterone, sex hormone-binding globulin, estradiol (E2), and inhibin, were measured.
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15350181 Cocco P, Loviselli A, Fadda D, Ibba A, Melis M, Oppo A, Serra S, Taberlet A, Tocco MG, Flore C: Serum sex hormones in men occupationally exposed to dichloro-diphenyl-trichloro ethane (DDT) as young adults. J Endocrinol. 2004 Sep;182(3):391-7.


To explore endocrine effects in relation to para,para'-dichloro-diphenyl-dichloro ethylene (p,p'-DDE) body burden and past occupational exposure to its precursor dichloro-diphenyl-trichloro ethane (DDT), we assayed serum sex hormones, including serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), 17beta-estradiol (E2), testosterone and sex hormone binding globulin (SHBG), and p,p'-DDE levels in 107 male participants in a 1946-1950 anti-malarial campaign in Sardinia, Italy.
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