Protein Information

Name sex hormone binding globulin
Synonyms ABP; SBP; Androgen binding protein; SHBG; Sex hormone binding globulin; Sex hormone binding globulin precursor; Sex steroid binding protein; TeBG…

Compound Information

Name DDT
CAS 1,1′-(2,2,2-trichloroethylidene)bis[4-chlorobenzene]

Reference List

PubMed Abstract RScore(About this table)
15556074 Tollefsen KE, Ovrevik J, Stenersen J: Binding of xenoestrogens to the sex steroid-binding protein in plasma from Arctic charr (Salvelinus alpinus L.). Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):127-33.

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16901337 Dalvie MA, Myers JE: The relationship between reproductive outcome measures in DDT exposed malaria vector control workers: a cross-sectional study. J Occup Med Toxicol. 2006 Aug 10;1:21.


Tests included blood basal and post gonadotrophin releasing hormone (GnRH), luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone, sex hormone binding globulin (SHBG), estradiol (E2) and inhibin; a questionnaire (demographics and general medical history); a physical examination and semen analysis.
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15261779 Dalvie MA, Myers JE, Lou Thompson M, Dyer S, Robins TG, Omar S, Riebow J, Molekwa J, Kruger P, Millar R: The hormonal effects of long-term DDT exposure on malaria vector-control workers in Limpopo Province, South Africa. Environ Res. 2004 Sep;96(1):9-19.


Serum o'p' and p'p' isomers of DDE, DDT, and DDD and basal and post-GnRH challenge hormone levels, including luteinizing hormone, follicle-stimulating hormone, testosterone, sex hormone-binding globulin, estradiol (E2), and inhibin, were measured.
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15350181 Cocco P, Loviselli A, Fadda D, Ibba A, Melis M, Oppo A, Serra S, Taberlet A, Tocco MG, Flore C: Serum sex hormones in men occupationally exposed to dichloro-diphenyl-trichloro ethane (DDT) as young adults. J Endocrinol. 2004 Sep;182(3):391-7.


To explore endocrine effects in relation to para,para'-dichloro-diphenyl-dichloro ethylene (p,p'-DDE) body burden and past occupational exposure to its precursor dichloro-diphenyl-trichloro ethane (DDT), we assayed serum sex hormones, including serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), 17beta-estradiol (E2), testosterone and sex hormone binding globulin (SHBG), and p,p'-DDE levels in 107 male participants in a 1946-1950 anti-malarial campaign in Sardinia, Italy.
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19247670 Ikonomopoulou MP, Olszowy H, Hodge M, Bradley AJ: The effect of organochlorines and heavy metals on sex steroid-binding proteins in vitro in the plasma of nesting green turtles, Chelonia mydas. J Comp Physiol B. 2009 Jul;179(5):653-62. Epub 2009 Feb 27.

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