Protein Information

Name thyroperoxidase
Synonyms MSA; TPO; TPO protein; TPX; Thyroid microsomal antigen; Thyroid peroxidase; Thyroid peroxidase isoform d variant; Thyroid peroxidase precursor…

Compound Information

Name DDT
CAS 1,1′-(2,2,2-trichloroethylidene)bis[4-chlorobenzene]

Reference List

PubMed Abstract RScore(About this table)
16107134 Langer P, Kocan A, Tajtakova M, Petrik J, Chovancova J, Drobna B, Jursa S, Pavuk M, Trnovec T, Sebokova E, Klimes I: Human thyroid in the population exposed to high environmental pollution by organochlorinated pollutants for several decades. Endocr Regul. 2005 Jan;39(1):13-20.


Serum levels of thyrotropin (TSH) and thyroid peroxidase antibodies (anti-TPO) were measured by specific sensitive immunoassays.
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17537484 Langer P, Tajtakova M, Kocan A, Petrik J, Koska J, Ksinantova L, Radikova Z, Ukropec J, Imrich R, Huckova M, Chovancova J, Drobna B, Jursa S, Vlcek M, Bergman A, Athanasiadou M, Hovander L, Shishiba Y, Trnovec T, Sebokova E, Klimes I: Thyroid ultrasound volume, structure and function after long-term high exposure of large population to polychlorinated biphenyls, pesticides and dioxin. Chemosphere. 2007 Aug;69(1):118-27. Epub 2007 May 29.


Serum levels of thyrotropin (TSH), thyroperoxidase antibodies (TPOab) and thyroglobulin were estimated by electrochemiluminiscent assay and these of 15 PCB congeners, p,p'-DDE, p,p'-DDT, hexachlorobenzene (HCB) and hexachlorocyclohexane by high-resolution gas chromatography.
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17222442 Langer P, Kocan A, Tajtakova M, Petrik J, Chovancova J, Drobna B, Jursa S, Radikova Z, Koska J, Ksinantova L, Huckova M, Imrich R, Wimmerova S, Gasperikova D, Shishiba Y, Trnovec T, Sebokova E, Klimes I: Fish from industrially polluted freshwater as the main source of organochlorinated pollutants and increased frequency of thyroid disorders and dysglycemia. Chemosphere. 2007 Apr;67(9):S379-85. Epub 2007 Jan 11.


Recently, a total of 2045 adults from this and the surrounding background pollution area have been examined using questionnaire data, thyroid volume by ultrasound (ThV), urinary iodine and serum levels of 15 PCB congeners, hexachlorobenzene (HCB), 2,2'-2-bis (4-chlorobiphenyl)-1,1-dichloroethylene (DDE), 2,2'-bis (4-chlorophenyl)-1,1,1-trichloroethane (DDT), alpha-, beta- and gamma-hexachlorocyclohexane (HCH), thyrotropin (TSH), free thyroxine (FT4), anti-thyroperoxidase antibodies (TPOab) and fasting glucose.
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