Protein Information

Name thymidylate synthases
Synonyms HsT422; TS; TMS; TSase; TYMS; Thymidylate synthase; Thymidylate synthetase; Thymidylate synthetase variant…

Compound Information

Name DDT
CAS 1,1′-(2,2,2-trichloroethylidene)bis[4-chlorobenzene]

Reference List

PubMed Abstract RScore(About this table)
15715461 Tondi D, Venturelli A, Ferrari S, Ghelli S, Costi MP: Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine. J Med Chem. 2005 Feb 24;48(4):913-6.

N,O-Didansyl-L-tyrosine (DDT) represented the starting lead for further development of novel non-substrate-like inhibitors of bacterial thymidylate synthase.
82(1,1,1,2) Details