| PubMed |
Abstract |
RScore(About this table) |
| 17035600 |
Medina-Diaz IM, Arteaga-Illan G, de Leon MB, Cisneros B, Sierra-Santoyo A, Vega L, Gonzalez FJ, Elizondo G: Pregnane X receptor-dependent induction of the CYP3A4 gene by o,p'-1,1,1,-trichloro-2,2-bis (p-chlorophenyl) ethane. Drug Metab Dispos. 2007 Jan;35(1):95-102. Epub 2006 Oct 11.
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9(0,0,0,9) |
Details |
| 15795092 |
Medina-Diaz IM, Elizondo G: Transcriptional induction of CYP3A4 by o,p'-DDT in HepG2 cells. Toxicol Lett. 2005 May 16;157(1):41-7.
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5(0,0,0,5) |
Details |
| 17692354 |
Petersen MS, Halling J, Damkier P, Nielsen F, Grandjean P, Weihe P, Brosen K: Polychlorinated biphenyl (PCB) induction of CYP3A4 enzyme activity in healthy Faroese adults. Toxicol Appl Pharmacol. 2007 Oct 15;224(2):202-6. Epub 2007 Jul 14.
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5(0,0,0,5) |
Details |
| 16764480 |
Mortensen AS, Arukwe A: The persistent DDT metabolite, 1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene, alters thyroid hormone-dependent genes, hepatic cytochrome P4503A, and pregnane X receptor gene expressions in Atlantic salmon (Salmo salar) Parr. Environ Toxicol Chem. 2006 Jun;25(6):1607-15.
Thyroid-stimulating hormone (TSHbeta), T4 deiodinase (T4ORD), thyroid receptors (TRalpha and TRbeta), and insulin-like growth factor type 1 receptor (IGF-1R) were analyzed using quantitative (real-time) polymerase chain reaction in liver, brain, and kidney, whereas cytochrome P4503A (CYP3A) and pregnane X receptor (PXR) mRNA levels were analyzed only in the liver. |
3(0,0,0,3) |
Details |
| 16054614 |
Kretschmer XC, Baldwin WS: CAR and PXR: xenosensors of endocrine disrupters? . Chem Biol Interact. 2005 Aug 15;155(3):111-28.
Furthermore, PXR and CAR induce enzymes, such as the CYP2B and CYP3A family members, responsible for the metabolism of steroid and thyroid hormones and this may alter their normal physiological function. |
1(0,0,0,1) |
Details |