Protein Information

Name aldehyde oxidase
Synonyms AO; AOH 1; AOH1; AOX 1; AOX1; Aldehyde Oxidase; Aldehyde oxidase 1; Aldeyde oxidase…

Compound Information

Name sulfur
CAS sulfur

Reference List

PubMed Abstract RScore(About this table)
19401776 Schumann S, Terao M, Garattini E, Saggu M, Lendzian F, Hildebrandt P, Leimkuhler S: Site directed mutagenesis of amino acid residues at the active site of mouse aldehyde oxidase AOX1. PLoS One. 2009;4(4):e5348. Epub 2009 Apr 29.

Mouse aldehyde oxidase (mAOX1) forms a homodimer and belongs to the xanthine oxidase family of molybdoenzymes which are characterized by an essential equatorial sulfur ligand coordinated to the molybdenum atom.
32(0,1,1,2) Details
19710232 Bernard DG, Cheng Y, Zhao Y, Balk J: An allelic mutant series of ATM3 reveals its key role in the biogenesis of cytosolic iron-sulfur proteins in Arabidopsis. Plant Physiol. 2009 Oct;151(2):590-602. Epub 2009 Aug 26.

Additional atm3 alleles were identified among sirtinol-resistant lines, correlating with decreased activities of aldehyde oxidases, cytosolic enzymes that convert sirtinol into an auxin analog, and depend on iron-sulfur (Fe-S) and molybdenum cofactor (Moco) as prosthetic groups.
31(0,1,1,1) Details
20164445 Teschner J, Lachmann N, Schulze J, Geisler M, Selbach K, Santamaria-Araujo J, Balk J, Mendel RR, Bittner F: A novel role for Arabidopsis mitochondrial ABC transporter ATM3 in molybdenum cofactor biosynthesis. Plant Cell. 2010 Feb;22(2):468-80. Epub 2010 Feb 17.

In ATM3 insertion mutants of Arabidopsis thaliana, the activities of nitrate reductase and sulfite oxidase were decreased to approximately 50%, whereas the activities of xanthine dehydrogenase and aldehyde oxidase, whose activities also depend on iron-sulfur clusters, were virtually undetectable.
7(0,0,1,2) Details
19793632 Sass JO, Gunduz A, Araujo Rodrigues Funayama C, Korkmaz B, Dantas Pinto KG, Tuysuz B, Yanasse Dos Santos L, Taskiran E, de Fatima Turcato M, Lam CW, Reiss J, Walter M, Yalcinkaya C, Camelo Junior JS: Functional deficiencies of sulfite oxidase: Differential diagnoses in neonates presenting with intractable seizures and cystic encephalomalacia. Brain Dev. 2009 Sep 28.

Sulfite oxidase is a mitochondrial enzyme encoded by the SUOX gene and essential for the detoxification of sulfite which results mainly from the catabolism of sulfur-containing amino acids.
Defects in the synthesis of the molybdenum cofactor are caused by mutations in one of the genes MOCS1, MOCS2, MOCS3 and GEPH and result in combined deficiencies of the enzymes sulfite oxidase, xanthine dehydrogenase and aldehyde oxidase.
1(0,0,0,1) Details
19741035 Alfaro JF, Joswig-Jones CA, Ouyang W, Nichols J, Crouch GJ, Jones JP: Purification and mechanism of human aldehyde oxidase expressed in Escherichia coli. Drug Metab Dispos. 2009 Dec;37(12):2393-8. Epub 2009 Sep 9.

The resulting protein is active, with sulfur being incorporated in the molybdopterin cofactor.
3(0,0,0,3) Details
20112869 Yang L, Liang J, Li H, Li L: Cloning and expression analysis of an aldehyde oxidase gene in Arachis hygogaea L. J Environ Biol. 2009 Jan;30(1):93-8.

Analysis of amino acid sequence of AhAO1 shows that it had 61%, 59% and 55% identity with the AOs from tomato, Arabidopsis and maize, respectively The peanut AO polypeptide contains consensus sequences for iron-sulfur centers and a molybdenum cofactor (MoCo)-binding domain.
3(0,0,0,3) Details