| Name | protein kinase C (protein family or complex) |
|---|---|
| Synonyms | Protein kinase C; PKC |
| Name | DDT |
|---|---|
| CAS | 1,1′-(2,2,2-trichloroethylidene)bis[4-chlorobenzene] |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12970576 | Hamel A, Mergler D, Takser L, Simoneau L, Lafond J: Effects of low concentrations of organochlorine compounds in women on transfer in human placental syncytiotrophoblast. Toxicol Sci. 2003 Nov;76(1):182-9. Epub 2003 Sep 11. They are by perturbation of Ca2+ channels and pumps, and they interfere with protein kinase C (PKC) and Ca2+ binding protein (CaBP). |
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| 16686424 | Mariussen E, Fonnum F: Neurochemical targets and behavioral effects of organohalogen compounds: an update. Crit Rev Toxicol. 2006 Mar;36(3):253-89. For instance, several reports have shown that OHCs alter neurotransmitter functions in CNS and Ca2+ homeostatic processes, induce protein kinase C (PKC) and phospholipase A2 (PLA2) mobilization, and induce oxidative stress. |
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| 19526567 | Magnarelli G, Souza MS, de D'Angelo AM: Heptachlor and o-p'DDT effects on protein kinase activities associated with human placenta particulate fractions. J Biochem Mol Toxicol. 2009 May;23(3):185-92. By contrast, protein kinase C activity was reduced by 10 microM HC and o-p' DDT (40% and 52%, respectively). |
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| 16322354 | Jajoo S, Mukherjea D, Pingle S, Sekino Y, Ramkumar V: Induction of adenosine A1 receptor expression by pertussis toxin via an ribosylation-independent pathway. J Pharmacol Exp Ther. 2006 Apr;317(1):1-10. Epub 2005 Dec 1. Chelation of intracellular Ca (2+) with 1,2-bis (2-aminophenoxy) ethane-N,N,N',N'-tetraacetic acid or inhibition of protein kinase C (PKC) with bisindolylmaleimide hydrochloride reduced the activation of NF-kappaB and [(3) H] DPCPX binding. |
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