| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | dieldrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7875126 | Rodriguez-Ariza A, Diaz-Mendez FM, Navas JI, Pueyo C, Lopez-Barea J: Metabolic activation of carcinogenic aromatic amines by fish exposed to environmental pollutants. Environ Mol Mutagen. 1995;25(1):50-7. Fish were treated with Aroclor 1254, pesticides (malathion and dieldrin), or (II), and compared to Aroclor 1254-treated rats. The promutagen activation capabilities of the S9 fractions were further characterized by studying the effect of two monooxygenase inhibitors, alpha-naphthoflavone, a well known inhibitor of aromatic hydrocarbon-inducible forms of cytochrome P450, and methimazole, a substrate for the flavin monooxygenase (FMO) system. |
1(0,0,0,1) | Details |
| 1215658 | Bellward GD, Dawson R, Otten M: The effect of dieldrin-contaminated feed on rat hepatic microsomal epoxide hydrase and aryl hydrocarbon hydroxylase. Res Commun Chem Pathol Pharmacol. 1975 Dec;12(4):669-84. Slight but significant increases in levels of cytochrome P-450 were observed. |
1(0,0,0,1) | Details |
| 3569844 | Haake J, Kelley M, Keys B, Safe S: The effects of organochlorine pesticides as inducers of and benzo [a] pyrene hydroxylases. Gen Pharmacol. 1987;18(2):165-9. p,p'-DDE, phenobarbital, dieldrin heptachlor, chlordane and toxaphene induced rat liver microsomes exhibited increased formation of the 4,5-dihydrodiol, 3,6- 9- and 3-hydroxymetabolites of benzo [a] pyrene and the latter three compounds also induced an increase in the rate of formation of the 9,10-dihydrodiol metabolite. Using a battery of monooxygenase enzyme assays it was evident that there were significant differences between PB and several organochlorine pesticides as inducers of rat hepatic cytochrome P-450-dependent monooxygenases. |
1(0,0,0,1) | Details |
| 817422 | Vainio H, Parkki MG: Enhancement of microsomal monooxygenase, epoxide hydrase and UDPglucuronyltransferase by aldrin, dieldrin and isosafrole administrations in rat liver. Toxicology. 1976 Mar;5(3):279-86. cytochrome c reducatase activkty was increased 2-fold, cytochrome P-450 content 1.2-fold, benzpyrene hydrozylase activity 2.5-fold and epoxide hydrase activity 1.2-fold after treatment of rats for 3 days. |
1(0,0,0,1) | Details |
| 11859874 | Hoyer AP, Gerdes AM, Jorgensen T, Rank F, Hartvig HB: Organochlorines, p53 mutations in relation to breast cancer risk and survival. Breast Cancer Res Treat. 2002 Jan;71(1):59-65. A non-significant increased risk of breast cancer was observed in the highest exposure level of dieldrin and polychlorinated biphenyls among women who developed a tumor with mutant p53 (odds ratio (OR) = 3.53, 95% confidence interval (CI) = 0.79-15.79 and OR = 3.00, 95% CI = 0.66-13.62). Initial attempts pursuing this avenue has dealt with polymorphisms in the carcinoge metabolizing enzymes cytochrome P450 (CYP1A1). |
1(0,0,0,1) | Details |
| 1680652 | Naidu AK, Naidu AK, Kulkarni AP: Aldrin epoxidation. Drug Metab Dispos. 1991 Jul-Aug;19(4):758-63. Dieldrin, the primary stable reaction product, was quantified by electron-capture gas chromatography. Catalytic potential of lipoxygenase as expressed in terms of its turnover numbers was approximately 4.0 nmol/min/nmol of enzyme, and it appears that lipoxygenase is up to 20 times a better catalyst of aldrin epoxidation than cytochrome P-450. |
1(0,0,0,1) | Details |
| 10706031 | Corrigan FM, Wienburg CL, Shore RF, Daniel SE, Mann D: Organochlorine insecticides in substantia nigra in Parkinson's disease. J Toxicol Environ Health A. 2000 Feb 25;59(4):229-34. Dieldrin (HEOD) was higher in PD brain than in AD or control brain, while 1,1'-(2,2-dichloroethenyl diene)-bis (4-chlorobenzene) (p,p-DDE) and total Aroclor-matched polychlorinated biphenyls (matched PCBs) were only higher in PD substantia nigra when these concentrations were compared with those of CLBD. |
0(0,0,0,0) | Details |
| 8504903 | Gilroy DJ, Carpenter HM, Siddens LK, Curtis LR: Chronic dieldrin exposure increases hepatic disposition and biliary excretion of [14C] dieldrin in rainbow trout. Fundam Appl Toxicol. 1993 Apr;20(3):295-301. |
0(0,0,0,0) | Details |
| 10914692 | Curtis LR, Hemmer MJ, Courtney LA: Dieldrin induces cytosolic [3H] 7, 12-dimethylbenz [a] anthracene binding but not multidrug resistance proteins in rainbow trout liver. J Toxicol Environ Health A. 2000 Jun;60(4):275-89. |
0(0,0,0,0) | Details |
| 8812264 | Gilroy DJ, Miranda CL, Siddens LK, Zhang Q, Buhler DR, Curtis LR: Dieldrin pretreatment alters [14C] dieldrin and [3H] 7,12-dimethylbenz [a] anthracene uptake in rainbow trout liver slices. Fundam Appl Toxicol. 1996 Apr;30(2):187-93. These changes may have important implications for OC bioaccumulation by rainbow trout and demonstrate an interaction between dieldrin and DMBA in the absence of cytochrome P450 system induction. |
81(1,1,1,1) | Details |
| 1098224 | Hayes JR, Hartgrove RW, Hundley SG, Campbell TC, Webb RE: Interaction of endrin and dieldrin with hepatic microsomal cytochrome P-450 from the rat, mouse, and endrin-susceptible and resistant pine voles. Toxicol Appl Pharmacol. 1975 Jun;32(3):559-65. |
81(1,1,1,1) | Details |
| 7427784 | Virgo BB: Unilaterally ovariectomized pregnant mice: dieldrin induction of the hepatic monooxygenases and plasma levels. Can J Physiol Pharmacol. 1980 Jun;58(6):638-42. By days 15--16, dieldrin had reduced the pentobarbital sleep time by 54% (P < 0.05), increased the liver mass by 8% (P < 0.05), and increased hepatic microsomal cytochrome P-450 by 66% (P < 0.05). |
81(1,1,1,1) | Details |
| 2888582 | Ronis MJ, Walker CH, Peakall D: Hepatic metabolism of cyclodiene insecticides by constitutive forms of cytochrome P-450 from lower vertebrates. Comp Biochem Physiol C. 1987;87(2):375-88. The metabolism of two organochlorine compounds, aldrin and the dieldrin analogue HCE, were studied in (a) intact microsomes and (b) reconstituted systems containing cytochrome P-450, from each of the five species. 5. |
36(0,1,1,6) | Details |
| 6780342 | Wolff T, Greim H, Huang MT, Miwa GT, Lu AY: Aldrin epoxidation catalyzed by purified rat-liver cytochromes P-450 and P-448. Eur J Biochem. 1980 Oct;111(2):545-51. Cytochrome P-450, purified from hepatic microsomes of phenobarbital-treated rats, exhibited a high rate of dieldrin formation. |
10(0,0,1,5) | Details |
| 15649640 | Dehn PF, Allen-Mocherie S, Karek J, Thenappan A: Organochlorine insecticides: impacts on human HepG2 cytochrome P4501A, 2B activities and levels. Toxicol In Vitro. 2005 Mar;19(2):261-73. This study examined the effects of the organochlorine (OC) insecticides chlordane, o,p'-DDT, dieldrin, endosulfan, kepone, methoxychlor, and toxaphene on human HepG2 cytochrome P450 (1A-EROD and 2B-PROD) activities and (GSH) levels. |
6(0,0,1,1) | Details |
| 8742319 | Kolaja KL, Stevenson DE, Johnson JT, Walborg EF Jr, Klaunig JE: Subchronic effects of dieldrin and phenobarbital on hepatic DNA synthesis in mice and rats. Fundam Appl Toxicol. 1996 Feb;29(2):219-28. Previous studies have shown that acute dietary exposure of rats or mice to either dieldrin or phenobarbital produces several liver changes, including centrilobular hypertrophy, induction of hepatic cytochrome P450, and increased liver weight. |
6(0,0,1,1) | Details |
| 201821 | Ishikawa T, McNeeley S, Steiner PM, Glueck CJ, Mellies M, Gartside PS, McMillin C: Effects of chlorinated hydrocarbon on plasma alpha-lipoprotein in rats. Metabolism. 1978 Jan;27(1):89-96. The hepatic microsomal cytochrome P-450 content of animals receiving Aroclor, dieldrin, and Kepone was 67%, 56%, and 44% higher than control values (p less than 0.02), indicating probable hepatic enzyme induction. |
6(0,0,1,1) | Details |
| 3606656 | Wolff T, Guengerich FP: Rat liver cytochrome P-450 isozymes as catalysts of aldrin epoxidation in reconstituted monooxygenase systems and microsomes. Biochem Pharmacol. 1987 Aug 15;36(16):2581-8. A novel aldrin metabolite, endo-dieldrin, was formed by cytochrome P-450UT-F in a 6-fold excess over dieldrin, which is the exo-isomer. |
5(0,0,0,5) | Details |
| 1201496 | Virgo BB, Bellward GD: Effect of dietary dieldrin on the liver and drug metabolism in the female Swiss-Vancouver mouse. Can J Physiol Pharmacol. 1975 Oct;53(5):903-11. Liver mass, hepatic microsomal protein and cytochrome P-450, and the in vitro metabolism of were determined at intervals. |
2(0,0,0,2) | Details |
| 9456078 | Khan MA, Jovanovich LV, Martin LT, Qadri SY, Podowski AA: Effects of photoisomers of cyclodiene insecticides on liver and microsomal cytochrome P450 in rats. Arch Toxicol. 1998;72(2):74-83. |
2(0,0,0,2) | Details |
| 7473857 | Nims RW, Lubet RA: Induction of cytochrome P-450 in the Norway rat, Rattus norvegicus, following exposure to potential environmental contaminants. J Toxicol Environ Health. 1995 Nov;46(3):271-92. In contrast, the chlorinated hydrocarbon pesticides, such as DDT, dieldrin, chlordane, and mirex, cause almost exclusively the induction of isoforms of the CYP2B (and to a lesser extent the CYP3A) subfamilies. |
2(0,0,0,2) | Details |
| 20211759 | Kamata R, Shiraishi F, Takahashi S, Shimizu A, Shiraishi H: Reevaluation of the developmental toxicity of dieldrin by the use of fertilized Japanese quail eggs. Comp Biochem Physiol C Toxicol Pharmacol. 2010 Mar 6. Other significant alterations in hatchlings were enlargement of the whole brain, decreases in mRNA expressions of tryptophan hydroxylase in the brainstem and side-chain cleavage in the male gonad, and increases in mRNA expressions of cytochrome P450 1A and 2C18 in the liver. |
1(0,0,0,1) | Details |
| 10725394 | Hold KM, Sirisoma NS, Ikeda T, Narahashi T, Casida JE: Alpha-thujone (the active component of absinthe): type A receptor modulation and metabolic detoxification. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3826-31. Most definitively, -induced peak currents in rat dorsal root ganglion neurons are suppressed by alpha-thujone with complete reversal after washout. alpha-Thujone is quickly metabolized in vitro by mouse liver microsomes with (cytochrome P450) forming 7--alpha-thujone as the major product plus five minor ones (4--alpha-thujone, 4-hydroxy-beta-thujone, two other hydroxythujones, and 7,8-dehydro-alpha-thujone), several of which also are detected in the brain of mice treated i.p. with alpha-thujone. |
1(0,0,0,1) | Details |
| 12049174 | Wei P, Zhang J, Dowhan DH, Han Y, Moore DD: Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response. Pharmacogenomics J. 2002;2(2):117-26. The products of the cytochrome P450 (CYP) genes play an important role in the detoxification of xenobiotics and environmental contaminants, and many foreign chemicals or xenobiotics can induce their expression. CAR is also required for the response of CYP2B10 to several additional xenobiotic inducers, including chlorpromazine, and dieldrin, but not dexamethasone, an agonist for both the xenobiotic receptor PXR (Pregnane X Receptor NR112) and the glucocorticoid receptor. |
1(0,0,0,1) | Details |
| 522518 | Pelkonen O, Moilanen ML: The specificity and multiplicity of human placental xenobiotic-metabolizing monooxygenase system studied by potential substrates, inhibitors and gel electrophoresis. Med Biol. 1979 Oct;57(5):306-12. Placental preparations from smokers catalyzed benzo (a) pyrene hydroxylation, 7-ethoxycoumarin O-deethylation and 2,5-diphenyloxazole hydroxylation, but not biphenyl hydroxylation at 2-, 3- or 4-carbon, aldrin epoxidation to dieldrin or hydroxylation or aminopyrine N-demethylation. Gel electrophoresis revealed that protein bands of placental microsomes in the region of cytochrome P-450 enzymes were less prominent than those of rat liver microsomes, a finding that accorded with the relative amounts of cytochrome P-450. |
1(0,0,0,1) | Details |
| 6618147 | Campbell MA, Gyorkos J, Leece B, Homonko K, Safe S: The effects of twenty-two organochlorine pesticides as inducers of the hepatic drug-metabolizing enzymes. Gen Pharmacol. 1983;14(4):445-54. The effects of 22 organohalogen pesticides as inducers of hepatic drug-metabolizing enzymes in the immature male Wistar rat have been determined, this group includes four isomeric hexachlorocyclohexanes, technical chlordane, alpha-chlordane, gamma-chlordane, oxychlordane, trans-nonachlor, heptachlor, heptachlor epoxide, aldrin, dieldrin, kepone, toxaphene, mirex, hexachlorobenzene (HCB) and several DDT analogs. With the exception of HCB, all of the pesticides induced microsomal dimethylaminoantipyrine, N-demethylase and aldrin epoxidase activities and the cytochrome P-450 content of microsomes from animals pretreated with most of the compounds was also increased compared to control rats. |
1(0,0,0,1) | Details |
| 15358766 | Zhang J, Huang W, Qatanani M, Evans RM, Moore DD: The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. J Biol Chem. 2004 Nov 19;279(47):49517-22. Epub 2004 Sep 8. Comparison of their responses to LCA treatment demonstrates that CAR predominantly mediates induction of the cytochrome p450 CYP3A11 and the multidrug resistance-associated protein 3 transporter, whereas PXR is the major regulator of the Na+-dependent organic anion transporter 2. As expected, they are completely insensitive to broad range xenobiotic inducers able to activate both receptors, such as and dieldrin. |
1(0,0,0,1) | Details |
| 12417264 | Coumoul X, Diry M, Barouki R: PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides. Biochem Pharmacol. 2002 Nov 15;64(10):1513-9. We have previously studied the down-regulation of induced CYP1A1 (cytochrome P450) expression by this class of molecules in mammary carcinoma cells and shown the importance of ERalpha in this process. |
1(0,0,0,1) | Details |
| 2866919 | Ronis MJ, Walker CH: Species variations in the metabolism of liposoluble organochlorine compounds by hepatic microsomal monooxygenase: comparative kinetics in four vertebrate species. Comp Biochem Physiol C. 1985;82(2):445-9. These results give evidence of cytochrome P-450 forms which can metabolize organochlorine compounds at low substrate concentrations. |
1(0,0,0,1) | Details |