| Name | alpha synuclein |
|---|---|
| Synonyms | Alpha synuclein; PARK4; PD1; NACP; Non A beta component of AD amyloid; Non A4 component of amyloid; Non A4 component of amyloid precursor; PARK 1… |
| Name | dieldrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15987830 | Sun F, Anantharam V, Latchoumycandane C, Kanthasamy A, Kanthasamy AG: Dieldrin induces ubiquitin-proteasome dysfunction in alpha-synuclein overexpressing dopaminergic neuronal cells and enhances susceptibility to apoptotic cell death. J Pharmacol Exp Ther. 2005 Oct;315(1):69-79. Epub 2005 Jun 29. Because recent evidence indicates that abnormal accumulation and aggregation of alpha-synuclein and ubiquitin-proteasome system dysfunction can contribute to the degenerative processes of PD, in the present study we examined whether the environmental pesticide dieldrin impairs proteasomal function and subsequently promotes apoptotic cell death in rat mesencephalic dopaminergic neuronal cells overexpressing human alpha-synuclein. |
249(2,4,8,9) | Details |
| 11445065 | Uversky VN, Li J, Fink AL: Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease. FEBS Lett. 2001 Jul 6;500(3):105-8. Here we show that several pesticides, including rotenone, dieldrin and paraquat, induce a conformational change in alpha-synuclein and significantly accelerate the rate of formation of alpha-synuclein fibrils in vitro. |
9(0,0,1,4) | Details |
| 16809432 | Richardson JR, Caudle WM, Wang M, Dean ED, Pennell KD, Miller GW: Developmental exposure to the pesticide dieldrin alters the system and increases neurotoxicity in an animal model of Parkinson's disease. FASEB J. 2006 Aug;20(10):1695-7. Epub 2006 Jun 29. Additionally, dieldrin exposure during development potentiated the increase in GFAP and alpha-synuclein levels induced by MPTP, indicating increased neurotoxicity. |
6(0,0,1,1) | Details |
| 16112328 | Kanthasamy AG, Kitazawa M, Kanthasamy A, Anantharam V: Dieldrin-induced neurotoxicity: relevance to Parkinson's disease pathogenesis. Neurotoxicology. 2005 Aug;26(4):701-19. Identification of key genetic defects such as alpha-synuclein and parkin mutations in PD also underscores the important role of genetic factors in the disease. |
1(0,0,0,1) | Details |
| 17291500 | Hatcher JM, Richardson JR, Guillot TS, McCormack AL, Di Monte DA, Jones DP, Pennell KD, Miller GW: Dieldrin exposure induces oxidative damage in the mouse nigrostriatal system. Exp Neurol. 2007 Apr;204(2):619-30. Epub 2007 Jan 5. Alpha-synuclein protein expression was also significantly increased in the striatum (25% increase). |
1(0,0,0,1) | Details |