Protein Information

Name p38
Synonyms AIMP 2; p38; AIMP2; JTV 1; JTV1; JTV1 gene; JTV1 protein; Multisynthetase complex auxiliary component p38…

Compound Information

Name dieldrin
CAS

Reference List

PubMed Abstract RScore(About this table)
18252963 Buteau-Lozano H, Velasco G, Cristofari M, Balaguer P, Perrot-Applanat M: Xenoestrogens modulate vascular endothelial growth factor secretion in breast cancer cells through an estrogen receptor-dependent mechanism. J Endocrinol. 2008 Feb;196(2):399-412.

Specific kinase inhibitors PD98059, SB203580, or LY294002 suppressed the xenoestrogen-induced VEGF response, suggesting activation of MEK, p38 kinase, and phosphatidylinositol-3-kinase pathways.
Genistein, bisphenol A (BPA), 4-(tert-octyl) phenol (OP), dieldrin, and several phthalates, including benzyl butyl phthalate (BBP) and di-ethyl-2-hexyle phthalate (DEHP), were first shown to be estrogenic.
1(0,0,0,1) Details
15770161 Kim DK, Kim JS, Kim JE, Kim SJ, Lee JS, Kim DJ, Son JH, Chun HS: Heme oxygenase-1 induction by dieldrin in dopaminergic cells. Neuroreport. 2005 Apr 4;16(5):509-12.

Furthermore, both the p38 and JNK mitogen-activated protein kinase pathways are utilized for HO-1 transcriptional activation by dieldrin.
31(0,1,1,1) Details
15888667 Ledirac N, Antherieu S, d'Uby AD, Caron JC, Rahmani R: Effects of organochlorine insecticides on MAP kinase pathways in human HaCaT keratinocytes: key role of reactive oxygen species. Toxicol Sci. 2005 Aug;86(2):444-52. Epub 2005 May 11.


The aim of this study was to investigate the effects of four OCs (dieldrin, endosulfan, heptachlor, and lindane) on mitogen-activated protein kinase (MAPK) cascades and more specifically to identify the mechanism underlying OC-induced ERK1/2 activation.
0(0,0,0,0) Details